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Primary Information | |
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| BoMiProt ID | Bomi104 |
| Protein Name | Alpha-S2-casein |
| Organism | Bos taurus |
| Uniprot ID | P02663 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776953.1 |
| Aminoacid Length | 222 |
| Molecular Weight | 26019 |
| FASTA Sequence | Download |
| Gene Name | CSN1S2 |
| Gene ID | 282209 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Endogenous/Bioactive peptides - Fragment - Sequence - Effect | 94–103 - QKALNEINQF - ACE inhibition Ref 163–176 - TKKTKLTEEEKNRL - ACE inhibition Ref |
| Protein Function | Have unique antibacterial properties; angiotensin- I enzyme inhibitor; serve to dampen allergenic responses; formation of health-promoting dairy products; inhibit calmodulin-activation of cyclic nucleotide phosphodiesterase; may be involved in promoting intestinal health and well being ; caprine caseins rich in αS2-CN offer enhanced sites for interactions with the common food additive κ-carrageenan |
| Biochemical Properties | occur primarily as a monomer with an internal disulfide; can form dimers with the chains either parallel or antiparallel to each other; αS2-CN is more sensitive to Ca2+ than αS1-CN with almost complete precipitation occurring in 2 mM Ca2+ for αS2-CN at pH 7; least susceptible to aggregation as initially purified from milk |
| Significance in milk | found to enhance calcium absorption resulted in the production of greater bone mass and correspondingly increased resistance to bone fracture in the rat femurs |
| PTMs | Phosphorylated; 11 phosphorylated serine residues; phosphorylated residues varies from 10 to 13 minor degrees of intermolecular disulfide bonding |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P02663|CASA2_BOVIN Alpha-S2-casein OS=Bos taurus OX=9913 GN=CSN1S2 PE=1 SV=2 MKFFIFTCLLAVALAKNTMEHVS*23S*24S*25EES*28IISQETYKQEKNMAINPS*46KENL CSTFCKEVVRNANEEEYSIGS*71S*72S*73EES*76AEVATEEVKITVDDKHYQKALNEI NQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENS KKTVDMES*158TEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQ HQKAMKPWIQPKTKVIPYVRYL |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | 25-42,46-47,60-78,135-160 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 6FS4, 6FS5, |
| Bibliography | 1. Spuergin, P., Mueller, H., Walter, M., Schiltz, E., & Forster, J. (1996). Allergenic epitopes of bovine alpha S1-casein recognized by human IgE and IgG. Allergy, 51(5), 306–312. https://doi.org/10.1111/j.1398-9995.1996.tb04614.x. 2. Masoodi, T. A., & Shafi, G. (2010). Analysis of casein alpha S1 & S2 proteins from different mammalian species. Bioinformation, 4(9), 430. 3. Farrell, H. M., Malin, E. L., Brown, E. M., & Mora-Gutierrez, A. (2009). Review of the chemistry of αS2-casein and the generation of a homologous molecular model to explain its properties. Journal of Dairy Science, 92(4), 1338–1353. https://doi.org/10.3168/jds.2008-1711. |