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Primary Information | |
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| BoMiProt ID | Bomi103 |
| Protein Name | Alpha-S1-casein |
| Organism | Bos taurus |
| Uniprot ID | P02662 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_851372.1 |
| Aminoacid Length | 214 |
| Molecular Weight | 24529 |
| FASTA Sequence | Download |
| Gene Name | CSN1S1 |
| Gene ID | 282208 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Endogenous/Bioactive peptides - Fragment - Sequence - Effect | α-casein exorphin - 90–96 - RYLGYLE - Opioid Ref α-casein exorphin - 90–95 - RYLGYL Opioid Ref α-casein exorphin - 91–96 - YLGYLE - Opioid Ref s1-Casokinin-5 - 23–27 - FFWAP - ACE inhibition Ref s1-Casokinin-7 - 28–34 - FPEWFGK - ACE inhibition Ref s1-Casokinin-6 -194–199 - TTMPLW - ACE inhibition, Immunomodulatory Ref 169–193 - LGTQYTDAPSFSDIPNPIGSENSEK - ACE-inhibition Ref |
| Protein Function | A major allergen |
| Biochemical Properties | acidic protein; isoelectric point 4.1-4.5; 17 proline residues, uniformly distributed over the molecule, and a high content (45%) of hydrophobic residues; random coil conformation; stabilized by hydrophobic interactions; contains sequential epitopes and only a few conformational epitopes |
| Significance in milk | found to enhance calcium absorption resulted in the production of greater bone mass and correspondingly increased resistance to bone fracture in the rat femurs |
| PTMs | Phosphoprotein; eight phosphorylated serine residues and a highly negatively charged region including residues 41-77; |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P02662|CASA1_BOVIN Alpha-S1-casein OS=Bos taurus OX=9913 GN=CSN1S1 PE=1 SV=2 MKLLILTCLVAVALARPKHPIKHQGLPQEV LNENLLRFFVAPFPEVFGKE KVNELSKDIGS*61ES*63TEDQAME DIKQMEAES*79IS*81S*82S*83EEIVPNS*90VEQKHIQKED VPSERYLGYLEQLLRLKKYKVPQLEIVPNS*130AEERLHSMKEGIHAQQKEPMIGVNQELAYFYPELFRQFYQLDAYPSGAWYYVPLGTQYTDAPSFSDIPNPIGSENSEKTTMPLW |
| Predicted Disorder Regions | 17-25,52-101,131-149,191-214 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Bibliography | 1. Spuergin, P., Mueller, H., Walter, M., Schiltz, E., & Forster, J. (1996). Allergenic epitopes of bovine alpha S1-casein recognized by human IgE and IgG. Allergy, 51(5), 306–312. https://doi.org/10.1111/j.1398-9995.1996.tb04614.x. 2. Masoodi, T. A., & Shafi, G. (2010). Analysis of casein alpha S1 & S2 proteins from different mammalian species. Bioinformation, 4(9), 430. 3. Farrell, H. M., Malin, E. L., Brown, E. M., & Mora-Gutierrez, A. (2009). Review of the chemistry of αS2-casein and the generation of a homologous molecular model to explain its properties. Journal of Dairy Science, 92(4), 1338–1353. https://doi.org/10.3168/jds.2008-1711. |