Primary Information |
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| BoMiProt ID | Bomi10262 |
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| Protein Name | Ubiquitin-conjugating enzyme E2 N/E2 ubiquitin-conjugating enzyme N/Ubiquitin carrier protein N/Ubiquitin-protein ligase N |
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| Organism | Bos taurus |
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| Uniprot ID | Q0P5K3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069726.1 |
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| Aminoacid Length | 152 |
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| Molecular Weight | 17138 |
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| FASTA Sequence |
Download |
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| Gene Name | UBE2N |
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| Gene ID | 541130 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The ubiquitin conjugating enzyme E2 N (UBE2N) is involved in the tumorigenesis of several tumors. |
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| Biochemical Properties | The ubiquitin conjugating enzyme E2 N (UBE2N), also known as Ubc13, is a member of the E2 ubiquitin-conjugating enzyme family.It has been proved that UBE2N heterodimerized with UBE2V1 and UBE2V2, and the heterodimers catalyzed the synthesis of noncanonical lysine-63-linked polyubiquitin chains, which did not lead to proteasome-dependent protein degradation, but mediated target genes' transcriptional activation. |
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| PTMs | N-6 Acetylation at Lys, Isopeptide bond formation,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Ubl Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin. |
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| Additional Comments | knockdown of UBE2N decreased the activation of MEK1/2 and p38 in cervical carcinoma cells, and UBE2N knockdown also markedly inhibited cervical carcinoma cell growth. |
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| Bibliography | 1.Song TT, Xu F, Wang W. Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma. Kaohsiung J Med Sci. 2020 Jul;36(7):501-507. doi: 10.1002/kjm2.12204. Epub 2020 Mar 20. PMID: 32196955. 2.Bailey J, Davis S, Shaw A, Diotallevi M, Fischer R, Benson MA, et al. Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation. Sci Rep. 2018;8:14310. 3.Hodge CD, Spyracopoulos L, Glover JN. Ubc13: the Lys63 ubiquitin chain building machine. Oncotarget. 2016;7:64471–64504. |
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