Primary Information |
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| BoMiProt ID | Bomi10231 |
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| Protein Name | Ubiquitin carboxyl-terminal hydrolase MINDY-2/Deubiquitinating enzyme MINDY-2/Protein FAM63B |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KI23 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039740.1 |
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| Aminoacid Length | 630 |
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| Molecular Weight | 68118 |
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| FASTA Sequence |
Download |
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| Gene Name | MINDY2/FAM63B |
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| Gene ID | 524749 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | deubiquitinase activity.removes 'Lys-48'-linked conjugated ubiquitin from proteins. |
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| Biochemical Properties | The catalytic domain of MINDY1/2 has five distinct Ub binding sites. Cys loop regulate DUB activity,Non-canonical catalytic triad composed of Cys-His-Thr, |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KI23|MINY2_BOVIN Ubiquitin carboxyl-terminal hydrolase MINDY-2 OS=Bos taurus OX=9913 GN=MINDY2 PE=2 SV=1
MESGPESLQPLEHGVAAGPAPGTGSPQEGQQETRLAAGDGPGVWAAESSGGKGQGAAAGG
RSLSDSASPAGSPQVLVPCSSLPRLDLKESDLES*94PAAQKEPVRGQHKVTASPETAEAGAD
HGLGPEGDGGARPDPAGTCQEESAAAGSSEPSSGGGLSSSCSDPSPPGESPSLDSLESFS
NLHSFPSSSEFNSEEGAENRVPEEEEGAAVLPGAVPLCGEEEVEEEEAQVLAASKERFPG
QSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYL
GDYMLDTKPKEISEIQRLNYEQNMSDAMAVLHKLQTGLDVNVKFTGVRVFEYTPECIVFD
LLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKIISCKQSENSELVSEGFVAEQFLNNT
ATQLTYHGLCELTSTVQEGELCVFFRNNHFSTMTKYKGLLYLLVTDQGFLTEEKVVWESL
HNVDGDGNFCDSEFHLRPPSDPETVYRGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEG
ISDLELAKKLQEEEDRRASQYYQEQEQAAAAAASASASASASASTQAPQSQPVQASPSSG
RQSGNSERKRKEPREKDKEKEKEKNSCVIL
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| Predicted Disorder Regions | 3 disordered segments; (1-213), (233-236), (502-510) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Abdul Rehman SA, Armstrong LA, Lange SM, Kristariyanto YA, Gräwert TW, Knebel A, Svergun DI, Kulathu Y. Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol Cell. 2021 Oct 21;81(20):4176-4190.e6. doi: 10.1016/j.molcel.2021.08.024. Epub 2021 Sep 15. PMID: 34529927; PMCID: PMC8550791. |
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