Search by BoMiProt ID - Bomi10218

Primary Information

BoMiProt ID Bomi10218
Protein Name Ubiquitin carboxyl-terminal hydrolase 21/Deubiquitinating enzyme 21/Ubiquitin thioesterase 21/Ubiquitin-specific-processing protease 21
Organism Bos taurus
Uniprot IDQ2KJ72
Milk FractionWhey
Ref Sequence ID NP_001039841.1
Aminoacid Length 565
Molecular Weight 62619
FASTA Sequence Download
Gene Name USP21
Gene ID 534273
Protein Existence Status Reviewed

Secondary Information

Protein Function cysteine proteases.removes ubiquitin groups from targets.such as in HIV infection ,it inhibits HIV-1 production by indirectly downregulating the expression of HIV-1 transactivator of transcription (Tat), which is essential for transcriptional elongation in HIV-1.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Gao W, Li G, Zhao S, Wang H, Huan C, Zheng B, Jiang C, Zhang W. Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression. J Virol. 2021 Jun 10;95(13):e0046021. doi: 10.1128/JVI.00460-21. Epub 2021 Jun 10. PMID: 33827943; PMCID: PMC8316079.