Primary Information
BoMiProt ID	Bomi10218
Protein Name	Ubiquitin carboxyl-terminal hydrolase 21/Deubiquitinating enzyme 21/Ubiquitin thioesterase 21/Ubiquitin-specific-processing protease 21
Organism	Bos taurus
Uniprot ID	Q2KJ72
Milk Fraction	Whey
Ref Sequence ID	NP_001039841.1
Aminoacid Length	565
Molecular Weight	62619
FASTA Sequence	Download
Gene Name	USP21
Gene ID	534273
Protein Existence Status	Reviewed
Secondary Information
Protein Function	cysteine proteases.removes ubiquitin groups from targets.such as in HIV infection ,it inhibits HIV-1 production by indirectly downregulating the expression of HIV-1 transactivator of transcription (Tat), which is essential for transcriptional elongation in HIV-1.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Gao W, Li G, Zhao S, Wang H, Huan C, Zheng B, Jiang C, Zhang W. Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression. J Virol. 2021 Jun 10;95(13):e0046021. doi: 10.1128/JVI.00460-21. Epub 2021 Jun 10. PMID: 33827943; PMCID: PMC8316079.