Primary Information |
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| BoMiProt ID | Bomi10215 |
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| Protein Name | Ubiquitin carboxyl-terminal hydrolase 16/Deubiquitinating enzyme 16/Ubiquitin thioesterase 16/Ubiquitin-specific-processing protease 16 |
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| Organism | Bos taurus |
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| Uniprot ID | Q08DA3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070335.1 |
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| Aminoacid Length | 826 |
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| Molecular Weight | 94050 |
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| FASTA Sequence |
Download |
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| Gene Name | USP16 |
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| Gene ID | 519992 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | required for period maintenance of the circadian clock at high temperature in Arabidopsis |
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| Biochemical Properties | Ubiquitin carboxyl-terminal hydrolases (UCHs) belong to an enzymatic subclass of DUBs, and are represented by three members in Arabidopsis, UCH1, UCH2 and UCH3. UCH1 and UCH2 infuence auxin-dependent developmental pathways in Arabidopsis through their deubiquitylation activities, whereas biological and enzymatic functions of UCH3 remain unclear. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08DA3|UBP16_BOVIN Ubiquitin carboxyl-terminal hydrolase 16 OS=Bos taurus OX=9913 GN=USP16 PE=2 SV=2
MGKKRTKGKTVPIDDSSESLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK
SEEETEENPSVWLCLKCGHQGCGRNSQEQHALKHYMKPRSEPHCLVLSLDNWSVWCYLCD
DEVHYCNSNRLGQVVDYVRKQAGNTTPESAEDNGNIELENKKLEKESKNEQEREKKENMA
RENPSMNS*188TSQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDL
ALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGIVTPRELFSQVCKKAVRFKGYQQQDSQ
ELLRYLLDGMRAEEHQRVSKGILKAFDNSTEKVDEELKNKVKEYEKKKSVPSFVDRIFGG
ELTSTIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSINDKNLKKTMEDEDKDS*414EEEKDN
DSYLKERNDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDVYAIDHPEDNEC
EVEMSLQREADIKSNHISQEEVAPKEYCVNQKDLNGHEKMIESITDNQKS*530TEEAAMKNVS
VDNDLEVLASS*551ATECPRNLNGAYLKEGSNGEVDISSGFENLNLNAALQPDEINIEILDDD
PTPGTKVYEVVNEDPETAFCTLANREAFNTDECSVQHCLYQFTRNEKLRDANKLLCEVCT
RRQYSGPKANMKGERKHIYTNAKKQMLISLAPPVLTLHFKRFQQAGFNLRKVNKHIKFPE
ILDLAPFCTLKCKNVAEEHTRVLYSLYGVVEHSGTMRSGHYTAYAKTRTASTHLSNLVLH
GDIPQDFEMESTKGQWFHISDTHVQAVPTTKVLSSQAYLLFYERIL
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| Predicted Disorder Regions | 1-16, 58-63, 149-177, 394-404, 432-521,584-588, 674-677 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | UCH3 was originally identifed through a mutant screen as a candidate gene necessary for activation of A. thaliana CONSTANS (CO), a key transcription factor that promotes fowering under long-day (LD) conditions. |
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| Bibliography | 1.Hayama, R., Yang, P., Valverde, F. et al. Ubiquitin carboxyl-terminal hydrolases are required for period maintenance of the circadian clock at high temperature in Arabidopsis. Sci Rep 9, 17030 (2019). https://doi.org/10.1038/s41598-019-53229-8 |
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