Primary Information |
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| BoMiProt ID | Bomi10198 |
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| Protein Name | Ubinuclein-2 |
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| Organism | Bos taurus |
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| Uniprot ID | E1B7L7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | XP_005205927.1 |
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| Aminoacid Length | 1330 |
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| Molecular Weight | 144390 |
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| FASTA Sequence |
Download |
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| Gene Name | UBN2 |
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| Gene ID | 540792 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Ubinuclein-2 (UBN2) is a nuclear protein that interacts with many transcription factors.It also promotes tumor progression in CRC.It may be used as a promising biomarker for predicting the prognosis of CRC patients. |
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| Biochemical Properties | The UBN2 protein belongs to the ubinuclein family, which exists in numerous human adult and fetal tissues.UBN1, an important paralog gene of UBN2 that encodes a partial ubinuclein polypeptide,was aberrantly expressed in many human cancers, including leukemia,CRC, lung carcinoma, cervical carcinoma, melanoma,as well as pancreatic adenocarcinoma. |
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| PTMs | N6-Acetylation at Lys, Isopeptide bond formation, Phosphorylation at Ser/Thr, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1B7L7|UBN2_BOVIN Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=1
MAEPRRVAFISLS*13PVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPR
SDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQ
PRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEML
AKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYI
NTGT*244LQFRQAS*251DT*253EEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPK
QLGVMALNSHKS*312EKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPP
SAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAAS*417NGS*420
PLS*423ESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFF
TQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREP
LQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGS*585EEDDEEKPGKRVIGP
RKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARM
LFKESRSVHNHLTSAPAKKKVIPAPKPKVKECSPKKDQKTPASSVASVGGPSTSSSTSAV
ASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAK
PRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGL
IAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSE
AQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDK
PLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAAS
PKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNA
LVAQSSHSSSNNPVHKQPSGMNISRQS*1107PTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTG
TVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSS
VVAASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLELLGF
GTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHAPLPTHVQQTFNDGGQSK
GDTKLPRKSQ
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| Predicted Disorder Regions | 14-56, 84-116, 140-161, 189-191, 272-322, 678-762, 799-1239, 1264-1299 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Knockdown of UBN2 inhibited the growth, invasiveness and metastasis of CRC cells via regulation of the Ras/MAPK signaling pathway. |
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| Bibliography | 1.Zhao YL, Zhong SR, Zhang SH, Bi JX, Xiao ZY, Wang SY, Jiao HL, Zhang D, Qiu JF, Zhang LJ, Huang CM, Chen XL, Ding YQ, Ye YP, Liang L, Liao WT. UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer. Cancer Cell Int. 2019 May 10;19:126. doi: 10.1186/s12935-019-0848-4. PMID: 31110467; PMCID: PMC6511126. 2.Aho S, Buisson M, Pajunen T, Ryoo YW, Giot JF, Grufat H, et al. Ubinuclein,a novel nuclear protein interacting with cellular and viral transcription factors. J Cell Biol. 2000;148(6):1165–76. |
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