Primary Information |
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| BoMiProt ID | Bomi10179 |
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| Protein Name | Tyrosine-protein kinase receptor Tie-1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q06805 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776390.1 |
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| Aminoacid Length | 1136 |
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| Molecular Weight | 124953 |
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| FASTA Sequence |
Download |
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| Gene Name | TIE1 |
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| Gene ID | 280941 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | endothelial specific cell surface protein,has proinflammatory property,maintaining vessel integrity. |
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| PTMs | phosphorylation,Glycosylation,Disulfide formation,regulated proteolytic cleavage. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q06805|TIE1_BOVIN Tyrosine-protein kinase receptor Tie-1 OS=Bos taurus OX=9913 GN=TIE1 PE=2 SV=1
MVWLEPPLLLPIFFLASHVGAAVDLTLLADLRLTEPQRFFLTCVSGEAGAGRGSDAWGPP
LLLEKDDRIVRTPRPWQPPHIARN*84GSSRVTVRGFSQPSDLVGVFSCVGGGGTRVLYVHNS
PGAHLLPDKVTHTVNKGDTAVLSARVRKEKQTDVIWKSN*159GSYFYTLDRHEAQDGQFLLQL
PNVQPSSSGIYSATYLEASPLGSAFFRLIVRGCEAGRWGQDCTKECPGCLHGGVCHDQDG
ECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTSGCRGLTFCLPDPYGCSCGSGWRGSQC
QEACAPGRFGADCHLQCQCQNGGTCDRFSGCVCPSGWHGMHCEKSDRIPQILDMVSELEF
NLDTMPRINCAAAGNPFPVRGSMELRKPDGTVLLSTKAIVEPDRTTAEFEVPRLALGDSG
LWECRVSTSGGQDSRRFRINVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPIASVRL
HYRPQDSTMAWSTIVVDPSEN*501VTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDC
PEPLLKPWLEGWHVEGPDRLRVSWSLPPVPGPLVGDGFLLRLWDGARGQERREN*594VSSPQA
RTALLTGLTPGTYYQLDVRLYHCTLLGPASPAARVLLPPSGPPAPRHLHAQALSDSEIQL
MWQRPEAAAGPISKYIVEVQVAGGSGDPLWMDVDRPEETSTIVRGLN*707ASTRYLFRVRASV
QGPGDWSNVVEQSTLGNGLQIEGPVQEIHAAEEGLDQQLVLAVVGSVSATCLTILAALLT
LACIRKSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLNYPVLEWEDITFE
DLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIIN
LLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASD
AANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVY*1005VKKTMGRLPVRWMAI
ESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQAYRMEQPRNCDDEV
YELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | When overexpressed in endothelial cells in vitro, Tie-1 is found to be tyrosine-phosphorylated,which probably upregulates VCAM-1, E-selectin, and ICAM-1, partly through a p38-dependent mechanism.regulated proteolytic cleavage which results in 2 fragments one is of 135kD which is fully glycosylated surface expressed receptor and and smaller one 46kD which corresponds to intracellular signaling. |
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| Bibliography | 1.Marron MB, Hughes DP, McCarthy MJ, Beaumont ER, Brindle NP. Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesis. Adv Exp Med Biol. 2000;476:35-46. doi: 10.1007/978-1-4615-4221-6_3. PMID: 10949653. 2.Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP. Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem Biophys Res Commun. 2008 Jul 4;371(3):475-9. doi: 10.1016/j.bbrc.2008.04.091. Epub 2008 Apr 28. PMID: 18448073. |
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