Primary Information |
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BoMiProt ID | Bomi10173 |
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Protein Name | Tyrosine-protein kinase CSK/C-Src kinase |
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Organism | Bos taurus |
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Uniprot ID | Q0VBZ0 |
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Milk Fraction | Whey,Exosome,MFGM |
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Ref Sequence ID | NP_001068865.1 |
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Aminoacid Length | 450 |
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Molecular Weight | 50633 |
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FASTA Sequence |
Download |
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Gene Name | CSK |
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Gene ID | 509246 |
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Protein Existence Status | Reviewed |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | leukocyte |
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Protein Function | c-Src kinase performs important activity not only on the plasma membrane but also within mitochondria for the regulation of osteoclastic bone resorption. |
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Biochemical Properties | C-terminal Src kinase consists of an SH3, SH2, and kinase domain; it lacks an N-terminal myristoyl group and a C-terminal regulatory tail. |
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PTMs | Phosphorylation at Ser/Tyr,N-acetylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0VBZ0|CSK_BOVIN Tyrosine-protein kinase CSK OS=Bos taurus OX=9913 GN=CSK PE=2 SV=1
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLCPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFFRSGWALNMKDLKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEY*304LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFS*364TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY*416EVMK
NCWHLDAATRPSFLQLREQLERIKTHELHL
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Phosphorylated at Ser-364 by PKA, leading to increased activity. |
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Bibliography | 1.Roskoski R Jr. Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1155-64. doi: 10.1016/j.bbrc.2004.09.171. PMID: 15504335. 2.Miyazaki T, Tanaka S, Sanjay A, Baron R. The role of c-Src kinase in the regulation of osteoclast function. Mod Rheumatol. 2006;16(2):68-74. doi: 10.1007/s10165-006-0460-z. PMID: 16633924. 3. |