Primary Information |
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BoMiProt ID | Bomi10140 |
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Protein Name | Tudor domain-containing protein 7 |
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Organism | Bos taurus |
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Uniprot ID | A6QLE1 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001093779.1 |
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Aminoacid Length | 1098 |
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Molecular Weight | 123899 |
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FASTA Sequence |
Download |
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Gene Name | TDRD7 |
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Gene ID | 506702 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | a class of chromatoid body components,responsible for ordered RNP remodeling of chromatoid bodies.participates in lens development and spermiogenesis as a mediator of autophagy. TDRD7-mediated autophagosome maturation is essential for lens fiber cell homeostasis and acrosome biogenesis. |
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Biochemical Properties | contains three OST-HTH (Oskar-Tdrd7-Helix-Turn-Helix)/LOTUS and three evolutionarily conserved tudor domains.OST-HTH/LOTUS domain regulate RNA metabolic processes. tudor domains bind to methylated arginine residues with in other proteins |
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PTMs | Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLE1|TDRD7_BOVIN Tudor domain-containing protein 7 OS=Bos taurus OX=9913 GN=TDRD7 PE=2 SV=1
MLEADLVSKMLRAVLQSHKNGIALPRLQGEYRSLTGDWIPFKQLGYPTLEAYLRSVPAVV
RIETSRSGEVTCYAVACTETARIAQLVARQRSSKRKTGRQVNCQMRVKKTMPFFLEGKPK
ATLRQPGFSSDFSVSKKPNSTLLRNKGISLGVKSDAEVLPYTLQTTIGNEVFKDVPVQSH
MTMSTNNRFSPKASLPPRFQMHLSRTCTKEMSDNLNQAVEKPNVTPPASYTYKMDEVQNR
IKEILNKHSNGIWISKLPHFYKELYKEELNQGILQQFEHWPHICTVEKPCSGGQDLLLYP
AKRKQLLRSELNTEKVPPS*319PLPAPKQIPPLKGCPAVMPGDFKEKVAELLVKYSSGLWASA
LPKTFEDMYKVKLPEDALKNLDLLSDVCTVDYISGNPQKAILYAKLPSPADKILKDAEQA
HGNYDIKSTVEQEYLQIEENIAESTDTFMETVTIPPLIIPTETSPSVLVVELSNTNEVVI
RYVGKDYSAAQELMEDEMKEYYSKNSKVTPVQTVQIGQLLAVNAEEDAWLRAQVISMEEG
KIKVCYVDYGFSENVEKSKAYRLNPKFCSLSFQATKCKLAGLEVLSDDPDLVKVVESLTC
GKIFAVEILEKTDIPLVVLYDTSGEDDININATCLKAICDKSLEVHLQVDAMYTNVRVTN
ICSDGTLYCQVPCKGLNKLNDLLHKIEEYFHCKHMTSEYFVSLPFCGKVCLFHCKGKWLR
VEITNVHSSRALDVQFLDAGTVTSVKVSELREIPPRFLQEMISVPPQAIKCCLADLPQSI
GMWTPDAVLWLRDSVLNCSDCSIKVTKVDETRGIAHIYLFTPKNFPDPHRSINRQITNAD
LWKHQKDVFLSAISSGASS*859PNTKSANTPILGNTGETFRKSLTDVLKKSVVNHPSSFFTKE
LPPPVHLSKPGEHMDVYVPVACHPGYFVIQPWQEIHKLEVLMEEMILYYSVSEERHVAVE
KDQVYAAKVENKWHRVLLKGILTNGLVSVYELDYGKHELVNMRKVQPLADMFRKLPFQAV
TAQLAGVKCNQWSEEASMVFRNHVEKKPLVALVQTVIENTNPWDRKVVVYLVDTSLPDTD
IWIHDFMSEYLVELSKVN
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Predicted Disorder Regions | 89-101, 316-324, 861-867 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Loss of function of TDRD7 leads to a syndrome that involves two developmentally and anatomically different organs, namely, the eye and testis. |
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Bibliography | Tu C, Li H, Liu X, Wang Y, Li W, Meng L, Wang W, Li Y, Li D, Du J, Lu G, Lin G, Tan YQ. TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation. Autophagy. 2021 Nov;17(11):3848-3864. doi: 10.1080/15548627.2021.1894058. Epub 2021 Mar 3. PMID: 33618632; PMCID: PMC8632297. |