Primary Information |
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| BoMiProt ID | Bomi10139 |
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| Protein Name | Tudor domain-containing protein 5 |
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| Organism | Bos taurus |
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| Uniprot ID | E1BPH3 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 975 |
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| Molecular Weight | 109626 |
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| FASTA Sequence |
Download |
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| Gene Name | TDRD5 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | novel component of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs), which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis |
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| Significance in milk | Regulates Milk Synthesis and Proliferation of Bovine Mammary Epithelial Cells |
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| PTMs | Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BPH3|TDRD5_BOVIN Tudor domain-containing protein 5 OS=Bos taurus OX=9913 GN=TDRD5 PE=3 SV=1
MSEQERIQECLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDM
PDVVSVCPCGDGTVILKAIPDESTKGIANLVAKQKSNHKVRNSMQKGRASVCSGPSSRRR
VPYRGRVPPILPAVVKSELKDLLALSPVLLSDFENAFANRFGRSFQYVQYGFLSMFEVLN
AASDVISVEQTRAGSLLTLKKSVSEEKQRGWPAAKGKIFTQPFRMKQQGSYPIGFPVAKA
CFSQPTSNMEPPKQILGMERNSRSNVMETSRLNHSEKLNQLALTLQSWVVSHYGFNGSFS
SAKKHKAMYTLRKFTENLMVCCLFNEYMLIFKEQLSPKKLGFLNVIELVGALSDILHVEF
REGEQDLLVFDADMKPLASVQPDKKTEAKACVSSPPRNSLSTAVIKETTWDCPSKNHKEP
EQKIFKKPNLVVKPLQLQVEINKSQLSLAVANHDIPPDAVRDKKLCRLPPLDTSTLVGVF
VEYILSPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYAMPECFIQPGHLCCVRI
SEDKWWYRVIIHRILGKQEVEVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWV
RPVEEHWTSRAVLQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGH
AIVCRENVPSKGFRDLNPLALYTKSSVTPEDIVLKELGYHSQQHYFNEDREISPQSKESD
LYTLDEIPTGMPYLESVTIGDDIWDENWLPLQAKMGKESDAASHLFTSSLGGKKPYPSCK
EIPQKDWCFSTPKDIWDDSWQPSGLVNGMKVEVQIPEGLGAQEKHIDTTRIQKQSNVKSA
SDSPALPKLEEFYISLIQSQQSAEGSQFEPSNIQTPPKQIQLSSTPTLVNS*891GSVEGSPES
LENEDFSSSSAITVFKDTSQGAVDQLSLILSPEHQISQKFYIPRSTATAALGAAARLATS
NSLLHWYPSVKKMET
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| Predicted Disorder Regions | 94-118, 383-387, 837-907 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M. TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 2011 Mar 7;192(5):781-95. doi: 10.1083/jcb.201009043. PMID: 21383078; PMCID: PMC3051809. |
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