Primary Information |
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| BoMiProt ID | Bomi10138 |
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| Protein Name | Tudor domain-containing protein 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2HJG4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039891.1 |
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| Aminoacid Length | 722 |
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| Molecular Weight | 80808 |
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| FASTA Sequence |
Download |
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| Gene Name | TDRD3 |
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| Gene ID | 537918 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | TDRD3 is a novel regulator of cell proliferation and invasion in breast cancer cells. |
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| Biochemical Properties | Tudor domain of the 'survival of motor neuron' protein and the Tudor domain-containing protein 3 (TDRD3) are highly similar and that they both have the ability to interact with arginine-methylated polypeptides. |
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| PTMs | Isopeptide bond formation,Ubl conjugation,Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2HJG4|TDRD3_BOVIN Tudor domain-containing protein 3 OS=Bos taurus OX=9913 GN=TDRD3 PE=2 SV=1
MAEAPGAALSRAGWYLSDEGIEACTSSPDKVNVNDIILIALNLEGPCVLQIQKIRNVAAP
KDNEESQAAPRMLRLQMTDGHISCTAVEFSYLSKISLNTPPGTKVKLSGAVDIKNGFLLL
NDSNTTVLGGEVEHLIEKWELQRSLSKHNRSNIGTEGGPPPFVPFGQKCVSHIQVDSREL
DRRKTLQVTMPVKPPNDNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNMHAAGNR
NREILQKEKANKSEGKHEGVYRELVDEKALRHITEMGFSKEASRQALMDNGNNLEAALNV
LLNSNKQKPVTGPPLRGKGKGRGRIRS*327EDEEELGNARPSAPSTLFDFLESKMGTLSVEEP
KSQPQQLHQGQNRVSNTEQNGVKDNNQPRYLPRNDTRQPRNEKPPRFQRDTQNSKAVLEG
SGLPRNRGSERPSTSSGSEGWAEERTKCDRSYSRYDRTKDTSYLLSSQHSDTVFKKRDNS
MQSRSGKGPSYTEAKENPFPQESVDYNNHKRGKRENQTANSDHFYDRKPRTINNEAFSGV
KIEKHFNVNTDYQHPVRMNSFIGVPNGETEMPLKGRRVGPIKPAGPIMASSCDDKIFYSS
GPKRRSGPIKPEKVLESSIPMEYAKLWKSGDECLALYWEDNKFYRAEVEALHSSGMTAVV
KFIDYGNYEEVLLSNIRPIQSEAWEEEGTYDQTLEFRRGGDGQPRRSTRPTQQFYQPPRA
RN
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| Predicted Disorder Regions | 222-226, 309-409, 454-461, 476-479, 704-722 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation suppresses its interaction with KLHL18 and downregulates its KLHL18-mediated degradation. Phosphorylation normally occurs under light conditions than dark conditions. |
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| Additional Comments | TDRD3 regulates the expression of a number of key genes associated with promotion of breast cancer tumorigenesis and disease progression. |
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| Bibliography | 1.Morettin A, Paris G, Bouzid Y, Baldwin RM, Falls TJ, Bell JC, Côté J. Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells. Sci Rep. 2017 Jul 11;7(1):5153. doi: 10.1038/s41598-017-04955-4. PMID: 28698590; PMCID: PMC5506013. 2.Goulet I, Boisvenue S, Mokas S, Mazroui R, Côté J. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. Hum Mol Genet. 2008 Oct 1;17(19):3055-74. doi: 10.1093/hmg/ddn203. Epub 2008 Jul 15. PMID: 18632687; PMCID: PMC2536506. |
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