|
|
|
Primary Information | |
|---|---|
| BoMiProt ID | Bomi10117 |
| Protein Name | Tubulin beta-2B chain |
| Organism | Bos taurus |
| Uniprot ID | Q6B856 |
| Milk Fraction | Whey,MFGM |
| Ref Sequence ID | NP_001003900.1 |
| Aminoacid Length | 445 |
| Molecular Weight | 49953 |
| FASTA Sequence | Download |
| Gene Name | TUBB2B |
| Gene ID | 281555 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | major constituent of microtubules. It binds 2 moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration. |
| Biochemical Properties | Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. |
| PTMs | Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q6B856|TBB2B_BOVIN Tubulin beta-2B chain OS=Bos taurus OX=9913 GN=TUBB2B PE=1 SV=2 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS*40DLQLERINVYYNEAT*55GNKYV PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPS*172PKVSDTVV EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALT*285VPELT*290QQMFDSKNMM AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATADEQGEFEEEEGEDEA |
| SCOP | Class : Alpha and beta proteins (a/b) Fold : Tubulin nucleotide-binding domain-like Superfamily : Tubulin nucleotide-binding domain-like Family : Tubulin, GTPase domain Domain Name : 1JFF B:2-245 Class : Alpha and beta proteins (a+b) Fold : Bacillus chorismate mutase-like Superfamily : Tubulin C-terminal domain-like Family : Tubulin, C-terminal domain Domain Name : 1JFF B:246-437 |
| CATH | Matched CATH superfamily 1.10.287.600 3.30.1330.20 3.40.50.1440 |
| Predicted Disorder Regions | 2 predicted disorder segments; (36-39),(412-445) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Polyglutamylation plays a key role in microtubule severing by spastin (SPAST).Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. |
| PDB ID | 1SA0,1SA1,1TVK,1Z2B,2P4N,2WBE,2XRP,3DCO,3DU7,3E22,3IZ0,3J1T,3J1U,3J2U,4AQV,4AQW,4ATU,4ATX,4CK5,4CK6,4CK7,4I4T,4I50,4I55,4IHJ,4IIJ,4O2A,4O2B,4O4H, 4O4I,4O4J,4O4L,4TUY,4TV8,4TV9,4UXO,4UXP,4UXR,4UXS,4UXT,4UXY,4UY0,4YJ2,4YJ3,5EIB,5EZY,5GON,5H74,5H7O,5HNW,5HNX,5HNY,5HNZ,5ITZ,5IYZ,5J2T,5J2U,5JH7,5JVD,5LA6,5LOV,5LP6,5LXS,5LXT,5LYJ,5M50,5M54,5M5C,5M5I,5M5L,5M5M,5M5N,5M5O,5M7E,5M7G,5M8D,5M8G,5MF4,5ND2,5ND3,5ND4,5ND7,5NFZ,5NG1,5NJH,5NM5,5NQT,5NQU,5O7A,5OSK,5OV7,5S4L,5S4M,5S4N,5S4O,5S4P,5S4Q,5S4R,5S4S,5S4T, |