Primary Information |
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| BoMiProt ID | Bomi101 |
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| Protein Name | Kininogen-1 |
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| Organism | Bos taurus |
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| Uniprot ID | P01044 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_786968.2 |
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| Aminoacid Length | 436 |
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| Molecular Weight | 48428 |
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| FASTA Sequence |
Download |
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| Gene Name | KNG1 |
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| Gene ID | 280833 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | tears, CSF, saliva |
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| Protein Function | accelerate the activation of
factor XII, prekallikrein, and factor XI as cofactor; Fragment 1.2 has also been shown to be
a potent inhibitor of the contact activation of factor XII; |
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| Biochemical Properties | rich in basic
amino acid residue, containing 22 histidines, 13 lysines,
and 3 arginines in a total of 110 residues; basic proteins such as
protamine, lysozyme, and synthetic polylysine inhibit
the activation for factor XII by a negatively charged
surface |
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| Significance in milk | maintaining the bone
strength and content of hydroxyproline |
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| PTMs | Bovine fragment 1.2 of HMW kininogen has four
oligosaccharide chains that attached to serine and
threonine residues. The residues with oligosaccharide
chains are S10, T10, T12, S18 from the amino-terminal of
the fragment 1.2; |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P01044|KNG1_BOVIN Kininogen-1 OS=Bos taurus OX=9913 GN=KNG1 PE=1 SV=1
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTF YSLKYQIKEGDCPFQSN*87KTWQDCDYKDSAQAATGECTATVAKRGNMKFSVAIQTCLITPA EGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNN*167N*168TSHSHLFDLKE VKRAQRQVVSGWNYEVN*197YSIAQTN*204CSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLY PVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKIDTVKKATVQVVAGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGS*398T*399T*400VSLPHS*406AMSP VQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHGSHGLGHGHQKQHGLGHGHKHGHG HGKHKNKGKNNGKHYDWRTPYLASSYEDST TS*512SAQTQEKT*520EETT*524LSSLAQPGVAIT*536FPDFQDSDLIAT*548VM PNT*553LPPHTESDDDWIPDIQT*570EPNSLAFKLIS*581DFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL |
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| Predicted Disorder Regions | 394-404,474-489,503-560,583-588,603-610 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Wilson, W. E., Lazarus, L. H., & Tomer, K. B. (1989). Bradykinin and kininogens in bovine milk. The Journal of Biological Chemistry, 264(30), 17777–17783. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2808351.
2. Yamamura, J. I., Takada, Y., Goto, M., Kumegawa, M., & Aoe, S. (2000). Bovine milk kininogen fragment 1·2 promotes the proliferation of osteoblastic MC3T3-E1 cells. Biochemical and Biophysical Research Communications, 269(2), 628–632. https://doi.org/10.1006/bbrc.2000.2326. |
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