Search by BoMiProt ID - Bomi10044


Primary Information

BoMiProt ID Bomi10044
Protein Name Triggering receptor expressed on myeloid cells 1/CD_antigen: CD354
Organism Bos taurus
Uniprot IDQ6QUN5
Milk FractionExosomes
Ref Sequence ID NP_996853.1
Aminoacid Length 232
Molecular Weight 25381
FASTA Sequence Download
Gene Name TREM1
Gene ID 404547
Protein Existence Status Reviewed

Secondary Information

Protein Function The triggering receptor expressed on myeloid cells 1 (TREM-1) is a receptor of the innate immune system, expressed mostly by myeloid cells and primarily associated with pro- inflammatory responses.
PTMs Disulfide bond formation,N-linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q6QUN5|TREM1_BOVIN Triggering receptor expressed on myeloid cells 1 OS=Bos taurus OX=9913 GN=TREM1 PE=2 SV=1 MRKAGVWGLLWMLFIEEIQAAAEVFEEKCTLAEGQTLKVSCPTNTNIYSNSQKAWQRLKD NGEVQTLAITEGSSQVRVGKYFLEDIPSEGMLQIQMANLQVEDSGLYRCVILGPSDPIIL FHPVRLVVTKNSLGTPASDEYPCQVSVQNPTPLPVTTKLRPRPRPRPKPVTQPIPTSADR LSSPGFTVTPTN*192VTHVNRAPGISIIIPAACGLLSKTLVFIGLFAVTHRSFAS
Predicted Disorder Regions 133-188
DisProt Annotation
TM Helix Prediction 1TMH; (204-226)
Additional Comments TREM-1 blockade may be a therapeutic possibility in certain inflammation-producing bacterial infections while potentially deleterious in others.
Bibliography 1.de Oliveira Matos A, Dos Santos Dantas PH, Figueira Marques Silva-Sales M, Sales-Campos H. The role of the triggering receptor expressed on myeloid cells-1 (TREM-1) in non-bacterial infections. Crit Rev Microbiol. 2020 May;46(3):237-252. doi: 10.1080/1040841X.2020.1751060. Epub 2020 Apr 24. PMID: 32326783. 2.Gallop D, Scanlon KM, Ardanuy J, Sigalov AB, Carbonetti NH, Skerry C. Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) Contributes to Bordetella pertussis Inflammatory Pathology. Infect Immun. 2021 Sep 16;89(10):e0012621. doi: 10.1128/IAI.00126-21. Epub 2021 Jun 7. PMID: 34097504; PMCID: PMC8445185.