Primary Information |
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| BoMiProt ID | Bomi10028 |
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| Protein Name | Transmembrane protein FAM155A |
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| Organism | Bos taurus |
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| Uniprot ID | A4IFM1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001077245.1 |
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| Aminoacid Length | 457 |
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| Molecular Weight | 50897 |
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| FASTA Sequence |
Download |
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| Gene Name | FAM155A |
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| Gene ID | 616912 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | calcium ion import across plasma membrane.Forms a complex with the NALCN channel which furthur mediates sodium leak currents, which positively adjust resting membrane potential towards depolarization. |
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| Biochemical Properties | The cysteine-rich domains of FAM155A are highly conserved and, thus, designated as the Mid1 domain. |
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| PTMs | Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A4IFM1|NALF1_BOVIN NALCN channel auxiliary factor 1 OS=Bos taurus OX=9913 GN=NALF1 PE=2 SV=1
MTRGAWMCRQYDDGLKIWLAAPRENEKPFIDSERAQKWRLSLASLLFFTVLLSDHLWFCA
EAKLTRARDKEQQQQQQQQQQRQQRQRQEQRQRQRQHEPSWPALLASMGEPSPAAQAHRL
LSASPSPTLPPSLGGGGGGKGGRGTDSRGKPPLPGNSARPAWRLETCYPQGASSGQCFTV
DSADAVCARNWSRGAAARGEQGQQTRGPPQPTPLWN*216LSDFYLSFCNSYTLWELFSGLSSP
NTLNCSLDVVLKEGGEMTTCRQCVEAYQDYDHHAQEKYEEFESVLHKYLQSEEYSVKSCP
EDCKIVYKAWLCSQYFEVAQLNCRKTIPCKQYCLEVQTRCPFILPDNDEVIYGGLSSFIC
TGLYETFLTNDEPECCDVRREAKPKSPSKGAGDRGGACPRTSLSASSAPRLGPSRLRLCV
LVLMLLHTVLTASVAHNATALGVGGVHTLDERSASEE
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| Predicted Disorder Regions | 24-34, 67-158, 195-211, 381-400, 449-457 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (40-58) |
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| Bibliography | Kang, Y., Wu, J. X., & Chen, L. (2020). Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex. Nature communications, 11(1), 6199. https://doi.org/10.1038/s41467-020-20002-9 |
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