Primary Information |
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| BoMiProt ID | Bomi10004 |
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| Protein Name | Transmembrane protein 184B |
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| Organism | Bos taurus |
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| Uniprot ID | A2VDL9 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 407 |
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| Molecular Weight | 45490 |
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| FASTA Sequence |
Download |
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| Gene Name | TMEM184B |
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| Gene ID | 514220 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | is critical for the maintenance of synaptic architecture.NMJ maintainenance |
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| PTMs | phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VDL9|T184B_BOVIN Transmembrane protein 184B OS=Bos taurus OX=9913 GN=TMEM184B PE=2 SV=1
MTVRGAALAPDPASPTTAAASPSISVIPEGSPTAMEQPVFLMTTAAQAISGFFVWTALLI
TCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFFTNDQYYVYFGTVRDCYEA
LVIYNFLSLCYEYLGGESSIMSEIRGKPIESSCMYGTCCLWGKTYSIGFLRFCKQATLQF
CVVKPLMAVSTVVLQAFGKYRDGDFDVTSGYLYVTIIYNISVSLALYALFLFYFATRELL
SPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKIHSARVSVGEGTVAAGYQDFIIC
VEMFFAALALRHAFTYKVYADKRVDAQGRCAPMKSISSSLKETMNPHDIVQDAIHNFSPA
YQQYTQQSTLEPGPTWRGGAHGLSRSHS*388LSGARDNEKTLLLS*402S*403DDEF
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| Predicted Disorder Regions | 10-24, 326-332, 364-407 |
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| DisProt Annotation | |
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| TM Helix Prediction | 6TMHs; (38-60), (80-102), (117-135), (180-198), (210-232), (239-261) |
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| Bibliography | Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. J Neurosci. 2016 Apr 27;36(17):4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016. PMID: 27122027; PMCID: PMC4846669. |
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