Search by BoMiProt ID - Bomi100

Primary Information

BoMiProt ID Bomi100
Protein Name Cystatin-C
Organism Bos taurus
Uniprot IDP01035
Milk FractionWhey
Ref Sequence ID NP_776454.1
Aminoacid Length 148
Molecular Weight 16265
FASTA Sequence Download
Gene Name CST3
Gene ID 281102
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells Parotid glands, osteoblast,
Protein Function Inhibits bone resorption; inhibits such proteases as papain and cathepsin B, L and K;
Significance in milk role in the protection from bacterial infection
PTMs 2 intracellular disulfide bonds; no glycosylation; chicken cystatin is phosphorylated;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (34-36)
DisProt Annotation
TM Helix Prediction 1TMH; (7-29)
Bibliography 1. Matsuoka, Y., Serizawa, A., Yoshioka, T., Yamamura, J., Morita, Y., Kawakami, H., … Kumegawa, M. (2002). Cystatin C in milk basic protein (MBP) and its inhibitory effect on bone resorption in vitro. Bioscience, Biotechnology, and Biochemistry, 66(12), 2531–2536.
2. Mudaliar, M., Tassi, R., Thomas, F. C., McNeilly, T. N., Weidt, S. K., McLaughlin, M., … Zadoks, R. N. (2016). Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), 2748–2761.