Search by BoMiProt ID - Bomi7944


Primary Information

BoMiProt ID Bomi7944
Protein Name Phosphatidylinositol 4-phosphate 5-kinase-like protein 1/PI(4)P 5-kinase-like protein 1/PtdIns(4)P-5-kinase-like protein 1
Organism Bos taurus
Uniprot IdQ17QS4
Milk FractionWhey
Ref Sequence Id NP_001069315.2
Aminoacid Length 396
Molecular Weight 44778
Fasta Sequence https://www.uniprot.org/uniprot/Q17QS4.fasta
Gene Name PIP5KL1
Gene Id 523736
Protein Existence Status reviewed

Secondary Information

Protein Function PIP5KL1 appears to be a potential tumour suppressor in cervical cancer development.
Biochemical Properties Two types of phosphoinositide kinase, designated type I PIPKs [also named as PIP5K (phosphatidylinositol 4- phosphate 5-kinases)], and type II PIPKs [also named as PIP4K (phosphatidylinositol 5-phosphate 4-kinases)] have been well characterized. Both type I and II PIPKs consist of a, b and c isoforms.Because of their close correlation with the development of human cancers.
PTMs Phosphorylation at Ser
Additional Comments Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells
Linking IDs Bomi7944
Bibliography 1.Shi L, Zhao M, Luo Q, Ma YM, Zhong JL, Yuan XH, Huang CZ. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Mol Biol Rep. 2010 Jun;37(5):2189-98. doi: 10.1007/s11033-009-9701-5. Epub 2009 Aug 13. PMID: 19680787. 2.Shi L, Wang K, Zhao M, Yuan X, Huang C. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. Cell Biol Int. 2010 Feb 22;34(3):309-15. doi: 10.1042/CBI20090040. PMID: 19947914.
Protein Function PIP5KL1 appears to be a potential tumour suppressor in cervical cancer development.
Biochemical Properties Two types of phosphoinositide kinase, designated type I PIPKs [also named as PIP5K (phosphatidylinositol 4- phosphate 5-kinases)], and type II PIPKs [also named as PIP4K (phosphatidylinositol 5-phosphate 4-kinases)] have been well characterized. Both type I and II PIPKs consist of a, b and c isoforms.Because of their close correlation with the development of human cancers.
PTMs Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-26, 74-86, 310-328
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells
Linking IDs
Bibliography 1.Shi L, Zhao M, Luo Q, Ma YM, Zhong JL, Yuan XH, Huang CZ. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Mol Biol Rep. 2010 Jun;37(5):2189-98. doi: 10.1007/s11033-009-9701-5. Epub 2009 Aug 13. PMID: 19680787. 2.Shi L, Wang K, Zhao M, Yuan X, Huang C. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. Cell Biol Int. 2010 Feb 22;34(3):309-15. doi: 10.1042/CBI20090040. PMID: 19947914.