Search by BoMiProt ID - Bomi2831


Primary Information

BoMiProt ID Bomi2831
Protein Name UBX domain-containing protein 4
Organism Bos taurus
Uniprot IdQ3ZBU9
Milk FractionExosome
Ref Sequence Id NP_001030491.2
Amino Acid Lenth 508
Molecular Weight 56784
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZBU9.fasta
Gene Name UBXN4
Gene Id 536181
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function Present typically at the carboxyl terminus of a variety of eukaryotic proteins; implicated in ubiquitination processes; a possible role for UBX domain-containing proteins in ubiquitin-related processes including protein degradation, endocytosis and DNA repair
Biochemical Properties Presence of protein domain displaying weak amino acid sequence homology to the small protein modifier ubiquitin ; cofactors for Cdc48/p97- belongs to the family of AAA ATPases; absence of a carboxy-terminal di-glycine motif, however, indicated that UBX domains are not covalently attached to target proteins in a ubiquitin-like manner; UBXD1 subfamily possess a central PUB domain in addition to the carboxy-terminal UBX domain
Linking IDs Bomi89
Bibliography 1. Rezvani, K., Teng, Y., Pan, Y., Dani, J. A., Lindstrom, J., García Gras, E. A., … De Biasi, M. (2009). UBXD4, a UBX-containing protein, regulates the cell surface number and stability of α3-containing nicotinic acetylcholine receptors. Journal of Neuroscience, 29(21), 6883–6896. https://doi.org/10.1523/JNEUROSCI.4723-08.2009.
2. Hofmann, R. M., & Pickart, C. M. (1999). Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell, 96(5), 645–653. https://doi.org/10.1016/s0092-8674(00)80575-9.