|Protein Name||UBX domain-containing protein 4|
|Ref Sequence Id||NP_001030491.2|
|Amino Acid Lenth||508|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Protein Function||Present typically at the carboxyl terminus of a variety of eukaryotic proteins; implicated in ubiquitination processes; a possible role for UBX domain-containing proteins in ubiquitin-related processes including protein degradation, endocytosis and DNA repair|
|Biochemical Properties||Presence of protein domain displaying weak amino acid sequence homology to the small protein modifier ubiquitin ; cofactors for Cdc48/p97- belongs to the family of AAA ATPases; absence of a carboxy-terminal di-glycine motif, however, indicated that UBX domains are not covalently attached to target proteins in a ubiquitin-like manner; UBXD1 subfamily possess a central PUB domain in addition to the carboxy-terminal UBX domain|
|Bibliography||1. Rezvani, K., Teng, Y., Pan, Y., Dani, J. A., Lindstrom, J., García Gras, E. A., … De Biasi, M. (2009). UBXD4, a UBX-containing protein, regulates the cell surface number and stability of α3-containing nicotinic acetylcholine receptors. Journal of Neuroscience, 29(21), 6883–6896. https://doi.org/10.1523/JNEUROSCI.4723-08.2009. |
2. Hofmann, R. M., & Pickart, C. M. (1999). Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell, 96(5), 645–653. https://doi.org/10.1016/s0092-8674(00)80575-9.