Search by BoMiProt ID - Bomi89


Primary Information

BoMiProt ID Bomi89
Protein Name UBX domain-containing protein 6
Organism Bos taurus
Uniprot IDQ2KIJ6
Milk FractionExosome
Ref Sequence ID NP_001039451.1
Aminoacid Length 441
Molecular Weight 49733
FASTA Sequence Download
Gene Name UBXN6
Gene ID 507936
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Present typically at the carboxyl terminus of a variety of eukaryotic proteins; implicated in ubiquitination processes; a possible role for UBX domain-containing proteins in ubiquitin-related processes including protein degradation, endocytosis and DNA repair
Biochemical Properties Presence of protein domain displaying weak amino acid sequence homology to the small protein modifier ubiquitin ; cofactors for Cdc48/p97- belongs to the family of AAA ATPases; absence of a carboxy-terminal di-glycine motif, however, indicated that UBX domains are not covalently attached to target proteins in a ubiquitin-like manner; UBXD1 subfamily possess a central PUB domain in addition to the carboxy-terminal UBX domain
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 12-57,62-81,86-113
DisProt Annotation
TM Helix Prediction No TM helices
Linking IDs
Bibliography 1. Rezvani, K., Teng, Y., Pan, Y., Dani, J. A., Lindstrom, J., García Gras, E. A., … De Biasi, M. (2009). UBXD4, a UBX-containing protein, regulates the cell surface number and stability of α3-containing nicotinic acetylcholine receptors. Journal of Neuroscience, 29(21), 6883–6896. https://doi.org/10.1523/JNEUROSCI.4723-08.2009.
2. Hofmann, R. M., & Pickart, C. M. (1999). Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell, 96(5), 645–653. https://doi.org/10.1016/s0092-8674(00)80575-9.