Search by BoMiProt ID - Bomi726


Primary Information

BoMiProt ID Bomi726
Protein Name DnaJ homolog subfamily C member 3
Organism Bos taurus
Uniprot IdQ27968
Milk FractionWhey
Ref Sequence Id NP_777181.1
Amino Acid Lenth 504
Molecular Weight 57704
Fasta Sequence https://www.uniprot.org/uniprot/Q27968.fasta
Gene Name DNAJC3
Gene Id 286770
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Protein Function DnaJ proteins, also known as heat shock protein 40 (Hsp40 or Hsc40) act as cochaperones to the molecular chaperone DnaK (Hsp70), which is responsible for several cellular processes such as rescuing misfolded proteins, folding polypeptide chains, transport of polypeptides through membranes, assembly and disassembly of protein complexes, and control of regulatory proteins; primarily facilitates the hydrolysis of ATP from DnaK that is necessary for the chaperone activity of DnaK; DNAJA1 appears to be involved in importing proteins into the mitochondria
Significance in milk heat stress proteins in mamary gland
Linking IDs Bomi56
Bibliography 1. Li, L., Sun, Y., Wu, J., Li, X., Luo, M., & Wang, G. (2015). The global effect of heat on gene expression in cultured bovine mammary epithelial cells. Cell Stress & Chaperones, 20(2), 381–389. https://doi.org/10.1007/s12192-014-0559-7.
2. Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., … Powers, R. (2014). Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry, 53(8), 1360–1372. https://doi.org/10.1021/bi401329a.