Search by BoMiProt ID - Bomi2652


Primary Information

BoMiProt ID Bomi2652
Protein Name DnaJ (Hsp40) homolog, subfamily B, member 2
Organism Bos taurus
Uniprot IdQ58DD3
Milk FractionExosome
Ref Sequence Id NP_001029764.1
Amino Acid Lenth 278
Molecular Weight 30707
Fasta Sequence https://www.uniprot.org/uniprot/Q58DD3.fasta
Gene Name DNAJB2
Gene Id 533668
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondry Information

Protein Function DnaJ proteins, also known as heat shock protein 40 (Hsp40 or Hsc40) act as cochaperones to the molecular chaperone DnaK (Hsp70), which is responsible for several cellular processes such as rescuing misfolded proteins, folding polypeptide chains, transport of polypeptides through membranes, assembly and disassembly of protein complexes, and control of regulatory proteins; primarily facilitates the hydrolysis of ATP from DnaK that is necessary for the chaperone activity of DnaK; DNAJA1 appears to be involved in importing proteins into the mitochondria
Significance in milk heat stress proteins in mamary gland
Linking IDs Bomi56
Bibliography 1. Li, L., Sun, Y., Wu, J., Li, X., Luo, M., & Wang, G. (2015). The global effect of heat on gene expression in cultured bovine mammary epithelial cells. Cell Stress & Chaperones, 20(2), 381–389. https://doi.org/10.1007/s12192-014-0559-7.
2. Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., … Powers, R. (2014). Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry, 53(8), 1360–1372. https://doi.org/10.1021/bi401329a.