Primary Information
BoMiProt ID	Bomi2346
Protein Name	Inositol monophosphatase 1
Organism	Bos taurus
Uniprot ID	P20456
Milk Fraction	Exosome
Ref Sequence ID	NP_776786.1
Aminoacid Length	277
Molecular Weight	30056
FASTA Sequence	Download
Gene Name	IMPA1
Gene ID	281865
Protein Existence Status	Reviewed: Experimental evidence at protein level
Secondary Information
Protein Function	IMPA1 is responsible for the generation of free inositol from de novo biosynthesis and recycling from inositol polyphosphates and participates in the phosphatidylinositol signaling pathway.
PTMs	Phosphorylation at Thr
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	IMPA1 mutation specifically affects NPC(neuronal progenitor cells) survival and neuronal differentiation.
Bibliography	1.Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M. Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2021 Jul;26(7):3558-3571. doi: 10.1038/s41380-020-00862-9. Epub 2020 Aug 24. PMID: 32839513.