Search by BoMiProt ID - Bomi2346

Primary Information

BoMiProt ID Bomi2346
Protein Name Inositol monophosphatase 1
Organism Bos taurus
Uniprot IDP20456
Milk FractionExosome
Ref Sequence ID NP_776786.1
Aminoacid Length 277
Molecular Weight 30056
FASTA Sequence Download
Gene Name IMPA1
Gene ID 281865
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function IMPA1 is responsible for the generation of free inositol from de novo biosynthesis and recycling from inositol polyphosphates and participates in the phosphatidylinositol signaling pathway.
PTMs Phosphorylation at Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  IMPA1 mutation specifically affects NPC(neuronal progenitor cells) survival and neuronal differentiation.
Bibliography 1.Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M. Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2021 Jul;26(7):3558-3571. doi: 10.1038/s41380-020-00862-9. Epub 2020 Aug 24. PMID: 32839513.