|Protein Name||Heat shock protein HSP 90-beta|
|Milk Fraction||Whey, MFGM, Exosome|
|Ref Sequence Id||NP_001073105.1|
|Amino Acid Lenth||724|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Protein Function||regulates efficient transport of peptides from the proteasome to MHC1; bind ATP; molecular chaperone normal unstressed cells; role in modifying antigen presentation; glial-axon transfer proteins; interact directly with fatty acids - interaction may be part of their mode of binding to cell membranes; resist noxious stimuli both in vitro and in vivo; ubiquitous expression of hsp70, hsp90, calreticulin and gp96 in cells essentially ensures that the MHC I presentation pathway remains functional in all nucleated cells; Hsp70 and hsp90 form heteromultimeric complexes in the cytosol with other co-chaperones; Hsp90 and hsp70 are intimately involved in the extrusion of antigens from the endosomes to the cytosol through a putative pore structure;protection of human monocytes from hydrogen peroxideinduced toxicity; guinea pig gastric mucosal cells from ethanol damage|
|Biochemical Properties||cytosolic HSP; Hsp90 has been shown to physically associate with the proteasome, and in certain instances replace the PA28 subunits; inhibitor is 17-AAG|
|Significance in milk||heat stress proteins in mamary gland|
|Significance of PTMs||sensitive to heat stress and mainly responsible for mammary cell protection from heat stress|
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