Search by BoMiProt ID - Bomi9992


Primary Information

BoMiProt ID Bomi9992
Protein Name Transmembrane protein 108/Retrolinkin
Organism Bos taurus
Uniprot IdA6QLF8
Milk FractionWhey
Ref Sequence Id NP_001095409.1
Aminoacid Length 583
Molecular Weight 60785
Fasta Sequence https://www.uniprot.org/uniprot/A6QLF8.fasta
Gene Name TMEM108
Protein Existence Status Reviewed

Secondary Information

Protein Function Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons.
PTMs Glycosylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 77-94, 116-155, 158-217, 261-419, 443-461, 547-555
DisProt Annotation
TM Helix Prediction 2TMHs ; (7-29) , (477-499)
Bibliography Jiao, H. F., Sun, X. D., Bates, R., Xiong, L., Zhang, L., Liu, F., Li, L., Zhang, H. S., Wang, S. Q., Xiong, M. T., Patel, M., Stranahan, A. M., Xiong, W. C., Li, B. M., & Mei, L. (2017). Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America, 114(5), 1177–1182. https://doi.org/10.1073/pnas.1618213114