Search by BoMiProt ID - Bomi9978


Primary Information

BoMiProt ID Bomi9978
Protein Name Translation initiation factor IF-3, mitochondrial/ IF-3(Mt)/ IF-3Mt/IF3(mt)/IF3mt
Organism Bos taurus
Uniprot IdQ32KZ1
Milk FractionWhey
Ref Sequence Id NP_001033155.1
Aminoacid Length 273
Molecular Weight 30619
Fasta Sequence https://www.uniprot.org/uniprot/Q32KZ1.fasta
Gene Name MTIF3
Gene Id 509987
Protein Existence Status reviewed

Secondary Information

Protein Function plays an active role in the initiation of translation in mammalian mitochondria
Biochemical Properties Mitochondrial translational initiation factor 3 (IF3(mt)) is a 29 kDa protein that has N- and C-terminal domains, homologous to prokaryotic IF3, connected by a linker region.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 31-69, 138-150, 243-273
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Mutation of residues 247 and 248 in the C-terminal extension abolished the ability of IF3(mt) to reduce the level of binding of fMet-tRNA to the ribosome in the absence of mRNA.
Bibliography Christian BE, Spremulli LL. Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria. Biochemistry. 2009 Apr 21;48(15):3269-78. doi: 10.1021/bi8023493. PMID: 19239245; PMCID: PMC3711378.