Primary Information |
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| BoMiProt ID | Bomi9977 |
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| Protein Name | Translation initiation factor eIF-2B subunit delta/eIF-2B GDP-GTP exchange factor subunit delta |
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| Organism | Bos taurus |
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| Uniprot Id | Q3T058 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001029716.1 |
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| Aminoacid Length | 524 |
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| Molecular Weight | 57469 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q3T058.fasta |
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| Gene Name | EIF2B4 |
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| Gene Id | 521926 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | necessary for protein synthesis.Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3T058|EI2BD_BOVIN Translation initiation factor eIF-2B subunit delta OS=Bos taurus OX=9913 GN=EIF2B4 PE=2 SV=1
MATAAVAVREDS*12GSGMKAELAPRPGAEGREMTQEEKLQLRKEKKQQKKKRKEEKGTETET
GSAVSAAQCQVGPAKHLAGPDSQLGT*86AKEKVPAGRSKAELRAERRAKQEAERAMKQARKG
DQGGPPPQACPSTAGETPSGVKRLPEHSQVDDPTLLRRLVKKPERQQVPTRKDYGSKVSL
FSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQD
YTTPPSEELSRDLVNKLKPYFSFLTQCRPLSASMYNAIKLLNKEITGVSGSKREEEAKSE
LRAAIDRYIKEKIVLAAQAISRFAYKKISNGDVILVYGCSSLVSHILQEAWAKGRQFRVV
VVDSRPRLEAKHTLRSLVRAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVG
TAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLLCERGEHVALANWQNH
SSLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
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| Predicted Disorder Regions | 10-152, 166-170 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Kashiwagi K, Takahashi M, Nishimoto M, Hiyama TB, Higo T, Umehara T, Sakamoto K, Ito T, Yokoyama S. Crystal structure of eukaryotic translation initiation factor 2B. Nature. 2016 Mar 3;531(7592):122-5. doi: 10.1038/nature16991. Epub 2016 Feb 22. PMID: 26901872. |
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