Search by BoMiProt ID - Bomi9976


Primary Information

BoMiProt ID Bomi9976
Protein Name Transketolase-like protein 2
Organism Bos taurus
Uniprot IdQ2NKZ4
Milk FractionWhey
Ref Sequence Id NP_001039490.1
Aminoacid Length 626
Molecular Weight 67501
Fasta Sequence https://www.uniprot.org/uniprot/Q2NKZ4.fasta
Gene Name TKTL2
Gene Id 509186
Protein Existence Status reviewed

Secondary Information

Protein Function Responsible for generating sugar phosphates for intracellular nucleotide metabolism as well as for the production of nicotinamide adenine dinucleotide phosphate (NADPH), a reducing agent and anti-oxidant.Links the pentose phosphate pathway (PPP), a non-oxidative glucose pathway (NOGP), to glycolysis.
Biochemical Properties homodimer and known thiamine diphosphate (TDP)-dependent enzyme that possesses two active sites located at the monomer contact surfaces.Ca2+,Mn2+ and Co2+ as cofactors.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Deshpande GP, Patterton HG, Faadiel Essop M. The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases. BMC Struct Biol. 2019 Jan 15;19(1):2. doi: 10.1186/s12900-018-0099-y. PMID: 30646877; PMCID: PMC6334435.