Search by BoMiProt ID - Bomi9964


Primary Information

BoMiProt ID Bomi9964
Protein Name Transforming growth factor-beta receptor-associated protein 1/ TGF-beta receptor-associated protein 1/TRAP-1/TRAP1
Organism Bos taurus
Uniprot IdA7MB11
Milk FractionWhey
Ref Sequence Id NP_001095478.1
Aminoacid Length 859
Molecular Weight 97006
Fasta Sequence https://www.uniprot.org/uniprot/A7MB11.fasta
Gene Name TGFBRAP1
Gene Id 514660
Protein Existence Status reviewed

Secondary Information

Protein Function TRAP1 is a previously described 96-kDa cytoplasmic protein shown to bind to TGF-beta receptors and suggested to play a role in TGF-beta signaling. 
Biochemical Properties Full-length TRAP1 Contains Multiple Receptor-binding Domains, and Single Domains Show Reduced Binding Specificity to establish the domains of TRAP1 involved in its binding to TbRII.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Deletion constructs of TRAP1 inhibit TGF-beta signaling and diminish the interaction of Smad4 with Smad2.
Bibliography 1.Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001 Jun 1;276(22):19495-502. doi: 10.1074/jbc.M006473200. Epub 2001 Feb 20. PMID: 11278302. 2.