Primary Information |
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BoMiProt ID | Bomi996 |
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Protein Name | Cyclic GMP-AMP synthase |
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Organism | Bos taurus |
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Uniprot ID | E1BGN7 |
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Milk Fraction | Exosome |
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Aminoacid Length | 498 |
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Molecular Weight | 55953 |
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FASTA Sequence |
Download |
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Gene Name | CGAS |
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Protein Existence Status | Reveiwed:Protein inferred from homology |
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Secondary Information |
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Protein Function | cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP. |
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PTMs | N-6 Acetylation at Lys-375,Isopeptide bond formation,Phosphorylation at Tyr-204 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1-135 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Acetylation at Lys-375, Lys-385 and Lys-405 gives rise to the inhibition of the cyclic GMP-AMP synthase activity. Phosphorylation at Tyr-204 by BLK promotes the cytosolic retention. |
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Additional Comments | Overexpression of cGAS activates the transcription factor IRF3 and induces interferon-β in a STING-dependent manner. |
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Bibliography | 1.Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20. PMID: 23258413; PMCID: PMC3863629. |