Search by BoMiProt ID - Bomi9941


Primary Information

BoMiProt ID Bomi9941
Protein Name Transcription factor Maf
Organism Bos taurus
Uniprot IdA7Z017
Milk FractionWhey
Ref Sequence Id NP_001099107.1
Aminoacid Length 377
Molecular Weight 38987
Fasta Sequence https://www.uniprot.org/uniprot/A7Z017.fasta
Gene Name MAF
Gene Id 782481
Protein Existence Status reviewed

Secondary Information

Protein Function  transcriptional activator or repressor.When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Activates the expression of IL4 in T-helper 2 (Th2) cells.
PTMs Phosphorylation and ubiquitination
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 8 disordered segments; (2-18), (29-41), (51-115), (126-163), (179-197), (223-246), (262-268), (301-309)
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity).By similarity Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (Probable). The phosphorylation status can serve to either stimulate or inhibit transcription
Bibliography Liu M, Zhao X, Ma Y, Zhou Y, Deng M, Ma Y. Transcription factor c-Maf is essential for IL-10 gene expression in B cells. Scand J Immunol. 2018 Sep;88(3):e12701. doi: 10.1111/sji.12701. Epub 2018 Aug 16. PMID: 29974486.