Search by BoMiProt ID - Bomi9929


Primary Information

BoMiProt ID Bomi9929
Protein Name Transcription factor 21/TCF-21
Organism Bos taurus
Uniprot IdQ5E9S3
Milk Fractionwhey
Ref Sequence Id NP_001014899.1
Aminoacid Length 179
Molecular Weight 19658
Fasta Sequence https://www.uniprot.org/uniprot/Q5E9S3.fasta
Gene Name TCF21
Gene Id 510873
Protein Existence Status Reviewed

Secondary Information

Protein Function Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types
PTMs SUMOylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions (1-92), (174-179)
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs SUMOylation plays a critical role in mediating the high expression of TCF21 in Stromal cells and may participate in the development of endometriosis.
Bibliography 1.Zhu J, Wu P, Zeng C, Xue Q. Increased SUMOylation of TCF21 improves its stability and function in human endometriotic stromal cells†. Biol Reprod. 2021 Jul 2;105(1):128-136. doi: 10.1093/biolre/ioab038. PMID: 33693540. 2.Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166