Search by BoMiProt ID - Bomi99


Primary Information

BoMiProt ID Bomi99
Protein Name AMBP
Organism Bos taurus
Uniprot IdP00978
Milk FractionWhey
Ref Sequence Id NP_776414.1
Amino Acid Lenth 352
Molecular Weight 39235
Fasta Sequence https://www.uniprot.org/uniprot/P00978.fasta
Gene Name AMBP
Gene Id 280996
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells Liver, blood, kidney, developing gut, vessel epithelia of the umbilical cord, pancreas
Protein Function codes for a polypeptide that gives rise to two different secreted proteins - α1-microglobulin and bikunin
Biochemical Properties α1-microglobulin binds a chromophore formed during heme-binding and degradation; bikunin is a proteinase inhibitor of the inter-a-inhibitor family
Significance in milk source of α trypsin inhibitors in milk;
Bibliography 1. Sánchez, D., Martínez, S., Lindqvist, A., Åkerström, B., & Falkenberg, C. (2002). Expression of the AMBP gene transcript and its two protein products, α1-microglobulin and bikunin, in mouse embryogenesis. Mechanisms of Development, 117(1–2), 293–298. https://doi.org/10.1016/S0925-4773(02)00202-2.
2. Allhorn, M., Berggård, T., Nordberg, J., Olsson, M. L., & Akerström, B. (2002). Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. Blood, 99(6), 1894–1901. https://doi.org/10.1182/blood.v99.6.1894.
3. Lindqvist, A., Rouet, P., Salier, J. P., & Akerström, B. (1999). The alpha1-microglobulin/bikunin gene: characterization in mouse and evolution. Gene, 234(2), 329–336. https://doi.org/10.1016/s0378-1119(99)00191-2.