Search by BoMiProt ID - Bomi9831


Primary Information

BoMiProt ID Bomi9831
Protein Name Thymosin beta-10/Thymosin beta-9
Organism Bos taurus
Uniprot IDP21752
Milk FractionWhey
Ref Sequence ID NP_777048.1
Aminoacid Length 42
Molecular Weight 4805
FASTA Sequence Download
Gene Name TMSB10
Gene ID 282385
Protein Existence Status reviewed

Secondary Information

Protein Function The 5 Kd (MW), retinoic acid responsive thymosin beta-10 protein is expressed at relatively high levels in embryonic tissues, and its mRNA is abundant in a variety of tumors and tumor cell lines.intracellular G-actin binding protein.plasmid-driven overexpression of thymosin beta-10 gene results in increased susceptibility of permanently transfected fibroblasts to undergo apoptosis.The presence of increased cytoplasmic thymosin beta-10 precipitated significant disruption of phalloidin-stained actin stress fibers while knockout of thymosin expression promoted F-actin assembly.controlling apoptosis possibly by acting as an actin-mediated tumor suppressor.
PTMs Acetylation on Lys and Ala, Phosphorylation on Ser and Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P21752|TYB10_BOVIN Thymosin beta-10 OS=Bos taurus OX=9913 GN=TMSB10 PE=1 SV=2 MADKPDLGEINS*12FDKAKLKKT*21ET*23QEKNTLPTKETIEQEKQAK
CATH Matched CATH superfamily
1.20.5.520
Predicted Disorder Regions Entirely disordered from 1 to 42
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1HJ0,
Bibliography Hall AK. Thymosin beta-10 accelerates apoptosis. Cell Mol Biol Res. 1995;41(3):167-80. PMID: 8589757.