Search by BoMiProt ID - Bomi9804


Primary Information

BoMiProt ID Bomi9804
Protein Name Thiopurine S-methyltransferase/Thiopurine methyltransferase
Organism Bos taurus
Uniprot IdQ17QQ2
Milk FractionExosomes
Ref Sequence Id NP_001068999.1
Aminoacid Length 245
Molecular Weight 28335
Fasta Sequence https://www.uniprot.org/uniprot/Q17QQ2.fasta
Gene Name TPMT
Gene Id 511644
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  placenta
Protein Function Thiopurine S-methyltransferase (TPMT) enzyme metabolizes thiopurine drugs which are widely used in various disciplines as well as in leukemias. 
PTMs N6-acetylation at Lysine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Thiopurine S-methyltransferase (TPMT) deficiency increases the risk of serious adverse events in persons receiving thiopurines.
Bibliography 1.Asadov C, Aliyeva G, Mustafayeva K. Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods. Cardiovasc Hematol Agents Med Chem. 2017 Nov 8;15(1):23-30. doi: 10.2174/1871525715666170529091921. PMID: 28552060; PMCID: PMC5740490. 2.Zur RM, Roy LM, Ito S, Beyene J, Carew C, Ungar WJ. Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy. Pharmacogenomics J. 2016 Aug;16(4):305-11. doi: 10.1038/tpj.2016.37. Epub 2016 May 24. PMID: 27217052; PMCID: PMC4957983.