Search by BoMiProt ID - Bomi9771


Primary Information

BoMiProt ID Bomi9771
Protein Name Testin
Organism Bos taurus
Uniprot IdQ2YDE9
Milk FractionWhey
Ref Sequence Id NP_001039855.1
Aminoacid Length 421
Molecular Weight 48049
Fasta Sequence https://www.uniprot.org/uniprot/Q2YDE9.fasta
Gene Name TES
Gene Id 534965
Protein Existence Status reviewed

Secondary Information

Protein Function  regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization,role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. maintain Sertoli-Sertoli junctions.
Biochemical Properties Zinc finger of LIM domain is essential for interaction with partner proteins.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 3-5, 133-171, 190-226
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK. Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling. Biochem Biophys Res Commun. 2011 Sep 9;412(4):584-9. doi: 10.1016/j.bbrc.2011.07.132. Epub 2011 Aug 6. PMID: 21843504. 2.Su L, Wang Z, Xie S, Hu D, Cheng YC, Mruk DD, Guan Y. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. J Cell Physiol. 2020 Sep;235(9):6127-6138. doi: 10.1002/jcp.29541. Epub 2020 Jan 24. PMID: 31975378.