Primary Information |
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BoMiProt ID | Bomi9764 |
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Protein Name | Tensin-4 |
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Organism | Bos taurus |
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Uniprot ID | Q32PJ7 |
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Milk Fraction | Whey,MFGM |
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Ref Sequence ID | NP_001033244.1 |
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Aminoacid Length | 716 |
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Molecular Weight | 75888 |
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FASTA Sequence |
Download |
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Gene Name | TNS4 |
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Gene ID | 532898 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton. |
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Biochemical Properties | The SH2 domain of tensin binds to focal adhesions.Tensin shares homology is an amino acid sequence with actin.The homologous regions of tensin and synapsin are highly positively charged (pb1 l), and it is conceivable that a target for both is a negatively charged moiety, such as the negatively charged surface of synaptic vesicles or the phospholipids associated with focal adhesions; this would be further evidence for a role for tensin in membrane interactions.
residues 223 to 25 1) which is a potential tropomyosin-binding site. |
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PTMs | phosphorylated on serine and threonine residues |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q32PJ7|TENS4_BOVIN Tensin-4 OS=Bos taurus OX=9913 GN=TNS4 PE=2 SV=2
MSQVMSSPLLAGGPAVGLAPCEEPRRVLHPAPSPSLPPPCPYYTTEGWGAQALMAPMPCK
GPPVRLQPAPQAGANASCLLKAPGEQVSGAQEDLDSYIDFSLESLNQMILELDPTFQLLP
PGPGGPEAQPTQSTTLGKKKEEPEALDIKYIEVTSTRSRCHDGPRSCCSPSVTPPFGSPR
TGGLLLSRDLPRETRSSSESLIFSGSQGRGHQHPAPPSAVPSSHPPTSPSISIPGMGSKA
SGPHGLGS*248PLVASPSLEKGLGGQGPQLSSRVSMLSGSPASDISYVFGSSQSLLHSSISSH
QSSSRSLESPSSSSSSLNNLGPVSLYTRASDLQVPSNATPSMGQPRATRSPPLAKEHASS
CPPSITNSMTDIPIVLINGFPEPGSPPSQRTPGPQDFVRPGATSSSMPCPATRSHSQTLP
EAPPTASPEGPARDMQPTMKFVMDTSKYWFKPSISREQAIELLRKEEPGAFIVRDSSSYR
GSFGLALKVQEAPTPAQSRPGEDSSDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQ
HSIMALALPCKLVIPQKELGGGDGASDPSADGQASCLKKSAGCHALYLSSVSVETLSGAL
AVEKAISATLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLATLRFCGMDPEQR
KWQKYCKPSRIFGFVAKSQTESQENVCHLFAEYDTLQPASQVIRLVGALLQDPERM
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Predicted Disorder Regions | 9 disordered segments; (2-7), (42-47), (67-134), (156-175), (216-256), (274-337), (353-368), (398-407), (561-581) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | under certain conditions it becomes highly tyrosine-phosphorylated.Tensin might also participate in serine threonine kinase mediated signal transduction. |
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Additional Comments | Tensin prevents and suppresses cellular transformation |
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Bibliography | Lo SH, Weisberg E, Chen LB. Tensin: a potential link between the cytoskeleton and signal transduction. Bioessays. 1994 Nov;16(11):817-23. doi: 10.1002/bies.950161108. PMID: 7840759. |