Primary Information
BoMiProt ID	Bomi9679
Protein Name	Syntaxin-5
Organism	Bos taurus
Uniprot ID	Q08DB5
Milk Fraction	Whey,MFGM
Ref Sequence ID	NP_001068912.1
Aminoacid Length	355
Molecular Weight	39546
FASTA Sequence	Download
Gene Name	STX5
Gene ID	510312
Protein Existence Status	reviewed
Secondary Information
Protein Function	Syntaxin-5 protects cells against proteotoxicity.It mediates endoplasmic reticulum to Golgi transport. Along with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus
Biochemical Properties	Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	1-14, 26-59, 81-85, 206-219
DisProt Annotation
TM Helix Prediction	1TMH; (334-352)
Significance of PTMs	Sed5 phosphorylation promotes dynamic movement of COPII-associated Hsp104 and boosts disaggregation by favoring anterograde ER-to-Golgi trafficking.Hsp104 is associated with COP vesicles, and the dynamic movement of soluble Hsp104 is regulated by Sed5 and its phosphorylation, consistent with COPII-dependent anterograde ER-Golgi transport also being involved in controlling Hsp104 movement.
Bibliography	1.Babazadeh R, Ahmadpour D, Jia S, Hao X, Widlund P, Schneider K, Eisele F, Edo LD, Smits GJ, Liu B, Nystrom T. Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress. Cell Rep. 2019 Aug 20;28(8):2096-2110.e8. doi: 10.1016/j.celrep.2019.07.053. PMID: 31433985. 2.Geng, L., Boehmerle, W., Maeda, Y., Okuhara, D. Y., Tian, X., Yu, Z., Choe, C. U., Anyatonwu, G. I., Ehrlich, B. E., & Somlo, S. (2008). Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15920–15925. https://doi.org/10.1073/pnas.0805062105