Search by BoMiProt ID - Bomi9679


Primary Information

BoMiProt ID Bomi9679
Protein Name Syntaxin-5
Organism Bos taurus
Uniprot IdQ08DB5
Milk FractionWhey,MFGM
Ref Sequence Id NP_001068912.1
Aminoacid Length 355
Molecular Weight 39546
Fasta Sequence https://www.uniprot.org/uniprot/Q08DB5.fasta
Gene Name STX5
Gene Id 510312
Protein Existence Status reviewed

Secondary Information

Protein Function Syntaxin-5 protects cells against proteotoxicity.It mediates endoplasmic reticulum to Golgi transport. Along with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus
Biochemical Properties Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-14, 26-59, 81-85, 206-219
DisProt Annotation
TM Helix Prediction 1TMH; (334-352)
Significance of PTMs Sed5 phosphorylation promotes dynamic movement of COPII-associated Hsp104 and boosts disaggregation by favoring anterograde ER-to-Golgi trafficking.Hsp104 is associated with COP vesicles, and the dynamic movement of soluble Hsp104 is regulated by Sed5 and its phosphorylation, consistent with COPII-dependent anterograde ER-Golgi transport also being involved in controlling Hsp104 movement.
Bibliography 1.Babazadeh R, Ahmadpour D, Jia S, Hao X, Widlund P, Schneider K, Eisele F, Edo LD, Smits GJ, Liu B, Nystrom T. Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress. Cell Rep. 2019 Aug 20;28(8):2096-2110.e8. doi: 10.1016/j.celrep.2019.07.053. PMID: 31433985. 2.Geng, L., Boehmerle, W., Maeda, Y., Okuhara, D. Y., Tian, X., Yu, Z., Choe, C. U., Anyatonwu, G. I., Ehrlich, B. E., & Somlo, S. (2008). Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15920–15925. https://doi.org/10.1073/pnas.0805062105