Search by BoMiProt ID - Bomi9622


Primary Information

BoMiProt ID Bomi9622
Protein Name Switch-associated protein 70
Organism Bos taurus
Uniprot IdP0C1G6
Milk FractionExosomes
Aminoacid Length 585
Molecular Weight 68921
Fasta Sequence https://www.uniprot.org/uniprot/P0C1G6.fasta
Gene Name SWAP70
Protein Existence Status Reviewed

Secondary Information

Protein Function SWAP-70, a phosphatidylinositol 3,4,5-trisphosphate-interacting, F-actin-binding protein, participates in actin rearrangements.It is also a guanine nucleotide exchange factor that participates in the regulation of many cellular processes.SWAP70 is a protective molecule that can suppress the progression of NAFLD by inhibiting hepatic steatosis and inflammation. SWAP70 may be important for mitigating the progression of NAFLD.
Biochemical Properties  SWAP-70's structure consists of an N-terminal putative EF-hand domain, a pleckstrin homology domain that binds phosphatidylinositol 3,4,5-trisphosphate and is responsible for membrane localization, a tri-partite coiled-coil region, and a C-terminal F-actin-binding site, through which SWAP-70 specifically binds nonmuscle but not muscle actin.
PTMs Phosphorylation at Tyr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 24-31, 60-62, 579-585
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Overexpression of SWAP70 in hepatocytes suppressed lipid deposition and inflammation
Bibliography 1.Qian Q, Li Y, Fu J, Leng D, Dong Z, Shi J, Shi H, Cao D, Cheng X, Hu Y, Luo Q, Hu M, Ran Y, Tang H, Liu H, Liu J. Switch-associated protein 70 protects against nonalcoholic fatty liver disease via suppression of TAK1. Hepatology. 2021 Oct 24. doi: 10.1002/hep.32213. Epub ahead of print. PMID: 34689362. 2.Ihara S., Oka T., Fukui Y. (2006) Direct binding of SWAP-70 to nonmuscle actin is required for membrane ruffling. J. Cell Sci. 119, 500–507. 3.Wakamatsu I., Ihara S., Fukui Y. (2006) Mutational analysis on the function of the SWAP-70 PH domain. Mol. Cell. Biochem. 293, 137–145. 4.