Search by BoMiProt ID - Bomi9619


Primary Information

BoMiProt ID Bomi9619
Protein Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2/60 kDa BRG-1/Brm-associated factor subunit B/BRG1-associated factor 60B
Organism Bos taurus
Uniprot IDE1BJD1
Milk FractionWhey
Ref Sequence ID NP_001192391.1
Aminoacid Length 531
Molecular Weight 58968
FASTA Sequence Download
Gene Name SMARCD2
Gene ID 789613
Protein Existence Status reviewed

Secondary Information

Protein Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
PTMs Isopeptide bond formation, Methylation, Phosphorylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|E1BJD1|SMRD2_BOVIN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Bos taurus OX=9913 GN=SMARCD2 PE=3 SV=1 MSGRGAGGFPLPPLSPGGGAVAAALGAPPPPAGPGMLPGPALRGPGPAGGVGGPGAAAFR PMGPAGPAAQYQRPGMSPGSRMPMAGLQVGPPAGSPFGTAAPLRPGMPPTMMDPFRKRLL VPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQTIARKRMEI QEAIKKPLTQKRKLRIYISNTFS*203PSKAEGDTAGTTGT*217PGGTPAGDKVASWELRVEGKLLD DPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDLNVKCTL LLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRYFR QIFSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQM SNFLASTTNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTDPQDFIQEWLRSQRRDLK IITDVIGNPEEERRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIRLT
Predicted Disorder Regions 3 disordered segments; (1-104), (133-144), (205-213)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt.
Bibliography 1.Lorès P, Visvikis O, Luna R, Lemichez E, Gacon G. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. FEBS J. 2010 Mar;277(6):1453-64. doi: 10.1111/j.1742-4658.2010.07575.x. Epub 2010 Feb 8. PMID: 20148946. 2.Zimin, A. V., Delcher, A. L., Florea, L., Kelley, D. R., Schatz, M. C., Puiu, D., Hanrahan, F., Pertea, G., Van Tassell, C. P., Sonstegard, T. S., Marçais, G., Roberts, M., Subramanian, P., Yorke, J. A., & Salzberg, S. L. (2009). A whole-genome assembly of the domestic cow, Bos taurus. Genome biology, 10(4), R42. https://doi.org/10.1186/gb-2009-10-4-r42