Primary Information |
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BoMiProt ID | Bomi9593 |
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Protein Name | Superoxide dismutase [Mn], mitochondrial |
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Organism | Bos taurus |
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Uniprot ID | P41976 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_963285.2 |
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Aminoacid Length | 222 |
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Molecular Weight | 24638 |
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FASTA Sequence |
Download |
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Gene Name | SOD2 |
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Gene ID | 281496 |
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Protein Existence Status | Reviewed |
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Secondary Information |
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Protein Function | mitochondrial superoxide dismutase (SOD2) is a major system converting diffusion-restricted superoxide radicals derived from the electron transport chain into highly diffusible hydrogen peroxide (H2O2). |
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PTMs | N6-acetylation at Lys,3'-nitration at Tyr, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Nitration coupled with oxidation inhibits the catalytic activity.Acetylation at Lys-122 decreases enzymatic activity.Polyubiquitinated; leading to proteasomal degradation. |
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Linking IDs | |
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Bibliography | 1.Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch. Antioxid Redox Signal. 2020 Apr 1;32(10):701-714. doi: 10.1089/ars.2019.7962. PMID: 31968997; PMCID: PMC7047081. |