Search by BoMiProt ID - Bomi9593


Primary Information

BoMiProt ID Bomi9593
Protein Name Superoxide dismutase [Mn], mitochondrial
Organism Bos taurus
Uniprot IdP41976
Milk FractionWhey
Ref Sequence Id NP_963285.2
Aminoacid Length 222
Molecular Weight 24638
Fasta Sequence https://www.uniprot.org/uniprot/P41976.fasta
Gene Name SOD2
Gene Id 281496
Protein Existence Status Reviewed

Secondary Information

Protein Function  mitochondrial superoxide dismutase (SOD2) is a major system converting diffusion-restricted superoxide radicals derived from the electron transport chain into highly diffusible hydrogen peroxide (H2O2). 
PTMs N6-acetylation at Lys,3'-nitration at Tyr, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs  Nitration coupled with oxidation inhibits the catalytic activity.Acetylation at Lys-122 decreases enzymatic activity.Polyubiquitinated; leading to proteasomal degradation.
Linking IDs
Bibliography 1.Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch. Antioxid Redox Signal. 2020 Apr 1;32(10):701-714. doi: 10.1089/ars.2019.7962. PMID: 31968997; PMCID: PMC7047081.