Primary Information |
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BoMiProt ID | Bomi9574 |
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Protein Name | Sulfatase-modifying factor 1/Formylglycine-generating enzyme |
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Organism | Bos taurus |
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Uniprot ID | Q0P5L5 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001069544.1 |
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Aminoacid Length | 374 |
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Molecular Weight | 40342 |
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FASTA Sequence |
Download |
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Gene Name | SUMF1 |
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Gene ID | 536435 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | is an O2 -utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. |
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Biochemical Properties | Copper enzyme. CuI is an integral cofactor of this enzyme and binds with high affinity (KD =of 10-17 m) to a pair of active-site cysteines. |
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Significance in milk | role in bovine testis metabolism |
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PTMs | N-glycosylated. Contains high-mannose-type oligosaccharides. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0P5L5|SUMF1_BOVIN Formylglycine-generating enzyme OS=Bos taurus OX=9913 GN=SUMF1 PE=2 SV=1
MAAPALGPARGCGAELTLVLLLSLFLLLGWAAGGEEAGPEAGAPSLVGSCGCGNPQRPGA
QGSSAAAHRYSREANAPGSVPGGRPSPPTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVA
IDAFYMDAYEVSNAEFEKFVN*147STGYLTEAEKFGDSFVFEGMLSEQVKSDIQQAVAAAPWW
LPVKGANWRHPEGPDSTVLHRPDHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLQ
NRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFRGTAPVDAFPPNGYGLYNIVGNAWE
WTSDWWTVHHSAEETINPKGPPSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASN
LGFRCAADHLPTTG |
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Predicted Disorder Regions | 3 disordered segments; (34-115), (314-337), (371-374) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Knop M, Dang TQ, Jeschke G, Seebeck FP. Copper is a Cofactor of the Formylglycine-Generating Enzyme. Chembiochem. 2017 Jan 17;18(2):161-165. doi: 10.1002/cbic.201600359. Epub 2016 Dec 13. PMID: 27862795; PMCID: PMC5324649. |