Primary Information |
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| BoMiProt ID | Bomi9476 |
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| Protein Name | Spondin-1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9GLX9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777168.1 |
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| Aminoacid Length | 807 |
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| Molecular Weight | 90976 |
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| FASTA Sequence |
Download |
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| Gene Name | SPON1 |
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| Gene ID | 282866 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | secreted by cells of the floor plate and may be involved in axon guidance. |
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| Protein Function | SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's disease mice model.Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites |
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| Biochemical Properties | is an extracellular matrix protein, consisting of three domains: spondin, reelin, and thrombospondin, and plays an essential role in neuronal survival and the migration of commissural axons.binds to the BACE1 cleavage site of APP and prohibits APP from being cleaved and released as the Aβ form |
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| Significance in milk | a mitogenic factor |
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| PTMs | Disulfide bond formation, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9GLX9|SPON1_BOVIN Spondin-1 OS=Bos taurus OX=9913 GN=SPON1 PE=1 SV=1
MRLSPVLLRLSRGPALLALALPLAVALAFSDETLDKVPKSEGYCSRILRVQGTRREGYTE
FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEE
ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK
LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS
KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA
PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG
VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD
NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC
PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGTGTRSRERYVKQFPEDGSVCTL
PTEETEKCTVNEECSPSSCLTTEWGEWDECSATCGMGMKKRHRMVKMSPADGSMCKAETS
QAEKCMMPECHTIPCLLSLWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEELEQVEKC
MLPECPIDCELTEWSQWSECN*681KSCGKGHMIRTRMIQMEPQFGGTPCPETVQRKKCRIRKC
LRNPSIQNLRWREARESRRSEQLREESDGDQFPGCRMRPWTAWSECTKLCGGGIQERYMT
VKKRFKSSQFTSCKDKKEIRACNVHPC |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Park SY, Kang JY, Lee T, Nam D, Jeon CJ, Kim JB. SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model. Cells. 2020 May 21;9(5):1275. doi: 10.3390/cells9051275. PMID: 32455709; PMCID: PMC7290723. |
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