Primary Information |
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| BoMiProt ID | Bomi9444 |
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| Protein Name | Spermatogenesis-associated protein 22 |
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| Organism | Bos taurus |
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| Uniprot Id | Q2TA20 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001033275.1 |
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| Aminoacid Length | 364 |
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| Molecular Weight | 41472 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q2TA20.fasta |
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| Gene Name | SPATA22 |
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| Gene Id | 539692 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Meiotic proteins involved in Meiosis steps.Also involved in a signaling cascade leading to DSB repair in oocytes and spermatocytes. |
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| Biochemical Properties | The mouse and human genes share similar structure, both being comprised of nine exons encoding for proteins of 358 and 363 amino acids, respectively |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | (1-203) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation of SPATA22,there are also two putative ATR and ATM phosphorylation sites along the sequence of SPATA22. ATR is required for XY body formation and MSUC, and ATM is involved in signaling DSB repair following initiation of meiotic recombination |
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| Additional Comments | In spermatocytes of Spata22-deficient mutant rats, meiosis was arrested at the zygotene-like stage, and a normal number of Rpa foci was observed during leptotene- and zygotene-like stages. |
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| Bibliography | Ishishita S, Matsuda Y, Kitada K. Genetic evidence suggests that Spata22 is required for the maintenance of Rad51 foci in mammalian meiosis. Sci Rep. 2014 Aug 21;4:6148. doi: 10.1038/srep06148. PMID: 25142975; PMCID: PMC4139951. |
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