Search by BoMiProt ID - Bomi9444


Primary Information

BoMiProt ID Bomi9444
Protein Name Spermatogenesis-associated protein 22
Organism Bos taurus
Uniprot IdQ2TA20
Milk FractionWhey
Ref Sequence Id NP_001033275.1
Aminoacid Length 364
Molecular Weight 41472
Fasta Sequence https://www.uniprot.org/uniprot/Q2TA20.fasta
Gene Name SPATA22
Gene Id 539692
Protein Existence Status reviewed

Secondary Information

Protein Function Meiotic proteins involved in Meiosis steps.Also involved in a signaling cascade leading to DSB repair in oocytes and spermatocytes.
Biochemical Properties The mouse and human genes share similar structure, both being comprised of nine exons encoding for proteins of 358 and 363 amino acids, respectively
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (1-203)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation of SPATA22,there are also two putative ATR and ATM phosphorylation sites along the sequence of SPATA22. ATR is required for XY body formation and MSUC, and ATM is involved in signaling DSB repair following initiation of meiotic recombination
Additional Comments In spermatocytes of Spata22-deficient mutant rats, meiosis was arrested at the zygotene-like stage, and a normal number of Rpa foci was observed during leptotene- and zygotene-like stages.
Bibliography Ishishita S, Matsuda Y, Kitada K. Genetic evidence suggests that Spata22 is required for the maintenance of Rad51 foci in mammalian meiosis. Sci Rep. 2014 Aug 21;4:6148. doi: 10.1038/srep06148. PMID: 25142975; PMCID: PMC4139951.