Search by BoMiProt ID - Bomi9247


Primary Information

BoMiProt ID Bomi9247
Protein Name Small nuclear ribonucleoprotein-associated protein N
Organism Bos taurus
Uniprot IdQ17QN3
Milk FractionWhey,MFGM
Ref Sequence Id NP_001073265.1
Aminoacid Length 240
Molecular Weight 24622
Fasta Sequence https://www.uniprot.org/uniprot/Q17QN3.fasta
Gene Name SNRPN
Gene Id 780877
Protein Existence Status reviewed

Secondary Information

Protein Function involved in tissue-specific alternative RNA processing events
PTMs Methylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 6 disordered segments; (1-9), (57-61), (82-176), (182-186), (192-212), (224-240)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs SNRPN-methylation is used to detect uniparental disomy of chromosome 15.decreased levels of the maternal allele methylation in the SNRPN DMR has been observed in children conceived by assisted reproductive technologies (ART), suggesting that the SNRPN methylation pattern is affected by in vitro culture systems.DMR methylation levels are found to be diminished in embryonic tissues in abnormal pregnancy.
Additional Comments Artificial reproductive techniques, such as prolonged in vitro culture and SCNT, lead to abnormal reprogramming of imprinting of SNRPN gene by altering methylation levels at this locus.
Bibliography Suzuki, J., Therrien, J., Filion, F. et al. In vitroculture and somatic cell nuclear transfer affect imprinting of SNRPN gene in pre- and post-implantation stages of development in cattle. BMC Dev Biol 9, 9 (2009). https://doi.org/10.1186/1471-213X-9-9