Search by BoMiProt ID - Bomi9132


Primary Information

BoMiProt ID Bomi9132
Protein Name SH3KBP1-binding protein 1
Organism Bos taurus
Uniprot IDA3KMV1
Milk FractionWhey
Ref Sequence ID NP_001076076.1
Aminoacid Length 704
Molecular Weight 75885
FASTA Sequence Download
Gene Name SHKBP1
Gene ID 512402
Protein Existence Status reviewed

Secondary Information

Protein Function promote EGFR signaling pathway by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation.
Biochemical Properties contains two PXXXPR motifs, which are bound to SH3 domains of CIN85. binding of SHKBP1 prevented the interaction of CIN85 with c-Cbl and inhibited the translocation of CIN85 to EGFR-containing vesicles.
PTMs Acetylation on Ala and phosphorylation on Ser and Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|A3KMV1|SHKB1_BOVIN SH3KBP1-binding protein 1 OS=Bos taurus OX=9913 GN=SHKBP1 PE=2 SV=1 MAAAAPAVDGVPGRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDET GAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLLEELDRSS CGNVLFTGYLPPPVFPVKRRNRHSLVGPQQAGGRPAPVRRSNT*163MPPNLGNAGLLGRMLDE KSPPSPSGLPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIER LALTARVLGGALGEHDKMVAVATGSEILLWALQPEGGGSEIGVFHLGVPVEALFFVGNQL IATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKD NDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGP QLFQTFTVHRSPVTKIMLSEKHLISVCADSNHVRTWSVTRFRGMISTQPGSTPLASFKIL ALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGS PTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEEELME QLEQCDLAPLASSRGSLPSPSPRTSLTSLHSAFSNTSLSSRRGS*644PS*646PPQAEARRRGGGSF VERCQELVRSGPEPRRPPTPAPRPSSGLGAPLVPPKTKLNETSF
Predicted Disorder Regions 5 disordered segments; (1-13), (148-168), (491-496), (590-646), (684-704)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Feng L, Wang JT, Jin H, Qian K, Geng JG. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Cell Biochem Funct. 2011 Oct;29(7):589-96. doi: 10.1002/cbf.1792. Epub 2011 Aug 9. PMID: 21830225; PMCID: PMC4534006.