Search by BoMiProt ID - Bomi9130


Primary Information

BoMiProt ID Bomi9130
Protein Name SH3 domain-binding glutamic acid-rich-like protein 2
Organism Bos taurus
Uniprot IdA4IFC4
Milk FractionExosomes
Ref Sequence Id NP_001077260.1
Aminoacid Length 107
Molecular Weight 12292
Fasta Sequence https://www.uniprot.org/uniprot/A4IFC4.fasta
Gene Name SH3BGRL2
Gene Id 785404
Protein Existence Status reviewed

Secondary Information

Protein Function A novel tumour suppressor.Loss of SH3BGRL2 was found to activate Hippo / TEAD1 / Twist1 signaling pathway and promote aggressiveness of clear cell renal cell carcinomas (ccRCC).
Biochemical Properties These small proteins contain a thioredoxin-like fold, SH3 binding domain, and glutamate-rich domain.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-3, 7-14, 46-73, 99-107
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments In Kaposi's Sarcoma, the loss of SH3BGR is due to expression of miR-K6-3p and induces cell migration and angiogenesis.when SH3BGRL is mutated (R76C), it binds and activates SRC and promotes metastasis.
Bibliography 1.Dufies M. SH3BGRL2, a new downregulated tumor suppressor in clear cell renal cell carcinomas. EBioMedicine. 2020 Feb;52:102641. doi: 10.1016/j.ebiom.2020.102641. Epub 2020 Jan 31. PMID: 32014821; PMCID: PMC6997511.