Search by BoMiProt ID - Bomi9111


Primary Information

BoMiProt ID Bomi9111
Protein Name SH2 domain-containing protein 1A
Organism Bos taurus
Uniprot IdQ3ZBB1
Milk FractionWhey
Ref Sequence Id NP_001029905.1
Aminoacid Length 128
Molecular Weight 14245
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZBB1.fasta
Gene Name SH2D1A
Gene Id 613356
Protein Existence Status reviewed

Secondary Information

Protein Function also known as SLAM(signaling lymphocytic activating molecules) associated protein, is a glycosylated type-I transmembrane protein, of relative molecular mass 70K, that is present on the surface of B and T cells; it is a high-affinity self-ligand.
Biochemical Properties contains an SH2 domain
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (104-128)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  X-linked lymphoproliferative disease (XLP) is due to mutation of this gene.
Bibliography Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998 Oct 1;395(6701):462-9. doi: 10.1038/26683. PMID: 9774102.