Primary Information | |
---|---|
BoMiProt ID | Bomi9064 |
Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform/CAM-PRP catalytic subunit/Calmodulin-dependent calcineurin A subunit alpha isoform |
Organism | Bos taurus |
Uniprot ID | P48452 |
Milk Fraction | Exosomes,MFGM |
Ref Sequence ID | NP_777212.1 |
Aminoacid Length | 521 |
Molecular Weight | 58672 |
FASTA Sequence | Download |
Gene Name | PPP3CA |
Gene ID | 286852 |
Protein Existence Status | Reviewed |
Secondary Information | |
Presence in other biological fluids/tissue/cells | brain and thymus |
Protein Function | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals. |
PTMs | N-acetylation at serine,3'-nitration at tyrosine,Phosphorylation at Serine |
PDB ID | 1TCO, 2F2O, 2F2P, |
Linking IDs | Bomi9064 |
Bibliography | 1.Selvakumar P, Lakshmikuttyamma A, Anderson DH, Sharma RK. Molecular cloning, expression, purification and characterization of calcineurin from bovine cardiac muscle. Biochimie. 2005 Nov;87(11):975-83. doi: 10.1016/j.biochi.2005.04.010. PMID: 15967565. 2.Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. doi: 10.1016/0092-8674(91)90124-h. PMID: 1715244. 3.Gaestel M, Benndorf R, Hayess K, Priemer E, Engel K. Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem. 1992 Oct 25;267(30):21607-11. PMID: 1328240. 4.Ye Q, Li X, Wong A, Wei Q, Jia Z. Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode. Biochemistry. 2006 Jan 24;45(3):738-45. doi: 10.1021/bi0521801. PMID: 16411749. |
Presence in other biological fluids/tissue/cells | brain and thymus |
Protein Function | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals. |
PTMs | N-acetylation at serine,3'-nitration at tyrosine,Phosphorylation at Serine |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P48452|PP2BA_BOVIN Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Bos taurus OX=9913 GN=PPP3CA PE=1 SV=1 MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEETV ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITS*469FEEAKGLDRIN ERMPPRRDAMPS*492DANLNSINKALASETNGTDSNGSNSSNIQ |
SCOP | Class : Alpha and beta proteins (a+b) Fold : Metallo-dependent phosphatases Superfamily : Metallo-dependent phosphatases Family : Protein serine/threonine phosphatase Domain Name : 1TCO A:21-372 |
CATH | Matched CATH superfamily 3.60.21.10 |
Predicted Disorder Regions | 1-10, 377-389, 435-520 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 1TCO, 2F2O, 2F2P, |
Linking IDs | |
Bibliography | 1.Selvakumar P, Lakshmikuttyamma A, Anderson DH, Sharma RK. Molecular cloning, expression, purification and characterization of calcineurin from bovine cardiac muscle. Biochimie. 2005 Nov;87(11):975-83. doi: 10.1016/j.biochi.2005.04.010. PMID: 15967565. 2.Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. doi: 10.1016/0092-8674(91)90124-h. PMID: 1715244. 3.Gaestel M, Benndorf R, Hayess K, Priemer E, Engel K. Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem. 1992 Oct 25;267(30):21607-11. PMID: 1328240. 4.Ye Q, Li X, Wong A, Wei Q, Jia Z. Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode. Biochemistry. 2006 Jan 24;45(3):738-45. doi: 10.1021/bi0521801. PMID: 16411749. |