Search by BoMiProt ID - Bomi9064


Primary Information

BoMiProt ID Bomi9064
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform/CAM-PRP catalytic subunit/Calmodulin-dependent calcineurin A subunit alpha isoform
Organism Bos taurus
Uniprot IDP48452
Milk FractionExosomes,MFGM
Ref Sequence ID NP_777212.1
Aminoacid Length 521
Molecular Weight 58672
FASTA Sequence Download
Gene Name PPP3CA
Gene ID 286852
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells brain and thymus 
Protein Function Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals.
PTMs N-acetylation at serine,3'-nitration at tyrosine,Phosphorylation at Serine
PDB ID 1TCO, 2F2O, 2F2P,
Linking IDs Bomi9064
Bibliography 1.Selvakumar P, Lakshmikuttyamma A, Anderson DH, Sharma RK. Molecular cloning, expression, purification and characterization of calcineurin from bovine cardiac muscle. Biochimie. 2005 Nov;87(11):975-83. doi: 10.1016/j.biochi.2005.04.010. PMID: 15967565. 2.Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. doi: 10.1016/0092-8674(91)90124-h. PMID: 1715244. 3.Gaestel M, Benndorf R, Hayess K, Priemer E, Engel K. Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem. 1992 Oct 25;267(30):21607-11. PMID: 1328240. 4.Ye Q, Li X, Wong A, Wei Q, Jia Z. Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode. Biochemistry. 2006 Jan 24;45(3):738-45. doi: 10.1021/bi0521801. PMID: 16411749.
Presence in other biological fluids/tissue/cells brain and thymus 
Protein Function Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals.
PTMs N-acetylation at serine,3'-nitration at tyrosine,Phosphorylation at Serine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P48452|PP2BA_BOVIN Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Bos taurus OX=9913 GN=PPP3CA PE=1 SV=1 MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEETV ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITS*469FEEAKGLDRIN ERMPPRRDAMPS*492DANLNSINKALASETNGTDSNGSNSSNIQ
SCOP Class : Alpha and beta proteins (a+b)
Fold : Metallo-dependent phosphatases
Superfamily : Metallo-dependent phosphatases
Family : Protein serine/threonine phosphatase
Domain Name : 1TCO A:21-372

CATH Matched CATH superfamily
3.60.21.10
Predicted Disorder Regions 1-10, 377-389, 435-520
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1TCO, 2F2O, 2F2P,
Linking IDs
Bibliography 1.Selvakumar P, Lakshmikuttyamma A, Anderson DH, Sharma RK. Molecular cloning, expression, purification and characterization of calcineurin from bovine cardiac muscle. Biochimie. 2005 Nov;87(11):975-83. doi: 10.1016/j.biochi.2005.04.010. PMID: 15967565. 2.Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. doi: 10.1016/0092-8674(91)90124-h. PMID: 1715244. 3.Gaestel M, Benndorf R, Hayess K, Priemer E, Engel K. Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem. 1992 Oct 25;267(30):21607-11. PMID: 1328240. 4.Ye Q, Li X, Wong A, Wei Q, Jia Z. Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode. Biochemistry. 2006 Jan 24;45(3):738-45. doi: 10.1021/bi0521801. PMID: 16411749.